Table.
Characteristics of trials included in meta-analysis of continuous subcutaneous insulin infusion versus intensive insulin injections
| Author | No of participants | Mean (SD or range) age (years) | Mean (SD or range) duration of diabetes (years) | Duration of treatment (months) | Type of pump | Type of insulin | Injection regimen |
|---|---|---|---|---|---|---|---|
| Schiffrin, 19828 | 16 | 24.9 (8.8) | 10.4 (5.1) | 6 | Mill Hill | Connaught/Lilly regular | Regular thrice daily; isophane insulin at bedtime |
| Home, 19826 | 10 | 40.4 (7.3) | 23.5 (8.3) | 2.5 | Mill Hill, Auto-Syringe | Pork Actrapid | Regular thrice daily; ultralente pm |
| Nathan, 19825 | 5 | 31 (5.7) | 7.4 (1.8) | 2-3 | Auto-Syringe | NA | Regular thrice daily; regular isophane insulin twice daily; ultralente before breakfast |
| Schiffrin, 198411 | 24 | 13-20 | 9 | 4 | Mill Hill | Connaught/Lilly regular | Regular thrice daily; isophane insulin pm/bedtime |
| Dahl-Jørgensen, 19867 | 15 | 26 (19-42)† | 12.8† | 24 | Nordisk | Pork Velosulin | Regular twice daily; isophane insulin am/bedtime |
| 15 | 26 (18-32)‡ | 12.8‡ | Auto-Syringe | ||||
| Helve, 198712 | 65 | 31.1 (1) | 12 (1) | 6 | Nordisk Auto-Syringe | Velosulin Actrapid | Multiple |
| Marshall, 198713 | 12 | 36 (21-50) | 18 (10-29) | 6 | Nordisk | Velosulin | Regular twice daily; isophane insulin twice daily/bedtime |
| Bak, 198714 | 20 | 24 (2) | 5.8 (3.8) | 6 | Graseby | Actrapid | Regular thrice daily; isophane insulin at bedtime |
| Saurbrey, 198816 | 21 | 32 (2.1) | 14.5 (1.4) | 2.5 | Auto-Syringe, Medix | NA | Regular thrice or four times daily; lente bedtime |
| Schmitz, 198917 | 10 | 36.5 (7.9) | 23.7 (2.9) | 6 | Nordisk | Velosulin | Regular thrice daily; isophane insulin at bedtime |
| Düsseldorf, 199018 | 47† | 32 (18-54) | 18 (3-44) | 24 | Nordisk, Promedos | NA | Regular twice, thrice, or four times daily |
| 49‡ | Betatron, Auto-Syringe | NA | Twice daily isophane insulin (or before breakfast injection/bedtime) | ||||
| Hannaire-Broutin, 200019 | 41 | 43.5 (10.3) | 20.0 (11.3) | 4 | MiniMed, Disetronic | Lispro | Thrice daily monomeric; twice daily isophane insulin (or before breakfast injection/bedtime) |
NA=data not available.
*
Regular=regular soluble or short acting insulin.
†
Participants on injections.
‡
Participants on pump therapy.