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. 2022 Jul 5;39(2):213–244. doi: 10.1007/s12264-022-00897-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Phenotypic and functional heterogeneity of fibroblasts in the glial scar. A Spatial maps showing the distribution of the three fibroblast clusters in the glial scar at different time points after injury. B UMAP spots showing the three clusters of fibroblasts in the glial scar. C UMAP spots embedding overlay showing the distribution of spots at different time points after injury. D Bar plot showing the fraction of all spots comprising each subpopulation at different time points after injury. E Jitterplot showing the top 5 differentially-expressed genes. F Spatial maps showing the GSVA scores of the ECM-receptor interaction pathway enrichment in cluster 2 cells and the glycosaminoglycan degradation pathway enrichment in cluster 1 cells at different time points after injury. G, H Trajectory of fibroblasts in the glial scar. I Heat map showing the upregulated or downregulated genes in different cell fates. J Violin plots showing the expression of Slc1a3 in the three clusters. K Dot plots showing the marker genes that best identify type A pericytes. L Pie chart showing the percentages of Slc1a3⁺ cells in the three fibroblast clusters (n = 32). M Violin plots and spatial maps showing the expression of Postn, a myofibroblast differentiation marker, at different time points after injury. N Violin plots and spatial maps showing the expression of Kng2 at different time points after injury. O Violin plots and spatial maps showing the expression of Saa3, an inflammatory ligand, at different time points after injury.