Fig. 5.

Pharmacological blockade of CD36 restrains fibrosis. A Experimental workflow and analysis for SAB treatment after T10 right lateral hemisection. B Representative images of injured mouse spinal cords treated with PBS and with SAB (50, 100, and 200 µg/mL) at 8 weeks post-infarction. The injury site is boxed in white. C, D SAB treatment reduces accumulation of P4HB⁺ cells in the scar core and promotes GFAP⁺ cells crossing the scar core and forming bridges in mice treated with SAB (200 µg/mL) (scale bar, 200 µm). E SAB treatment reduces the expression of CD36 in the scar core (scale bar, 100 µm).