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. 2022 Jul 5;39(2):213–244. doi: 10.1007/s12264-022-00897-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Phenotypic and functional heterogeneity of oligodendrocytes in the glial scar. A Spatial maps showing the distribution of 3 oligodendrocyte clusters in the glial scar at different time points after injury. B Bar plot showing the fraction of all spots comprising each subpopulation at different time points after injury. C Jitterplot showing the top 5 differentially expressed genes in each subpopulation. D Spatial maps showing the GSVA scores of ferroptosis pathway enrichment in cluster 0 cells, antigen processing and presentation pathway enrichment in cluster 1 cells, and synaptic vesicle cycle pathway enrichment in cluster 2 cells at different time points after injury. E, F Trajectory of oligodendrocytes in the glial scar. G Heat map showing the changes in gene expression along a spatial trajectory. H Expression of Ntm, Serpine1, Slc32a1, and Slc6a1 is correlated with pseudotime. I Heat map showing the enriched transcription factors by single-cell regulatory network inference and clustering analysis in different clusters after injury. J Violin plots and spatial maps showing the expression of Bmp7 at different time points after injury. K Violin plots and spatial maps showing the expression of CD74 at different time points after injury.