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. 2023 Jan 25;10:1014261. doi: 10.3389/fmed.2023.1014261

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Copyright © 2023 Luo, Liu, Lv, He, Qiang, Li, Huang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal pathology in mixed cryoglobulinemia. Light microscopy ( × 10). (A) PAS stain shows membranoproliferative glomerulonephritis characterized by nodular lobulated changes in glomeruli, segmentally thickened and double-contoured appearance of the glomerular basement membrane (black arrow), diffuse intracapillary cell accumulation, and inflammatory cell infiltration (red arrow). (B) Immunofluorescence studies showing Immunoglobulin G deposit in vascular loops with line-like (white arrow).