Table 1.
Clinical, US, thyroid function and pathological characteristics of patients undergoing PCLND in different groups.
| Variable | Group A (N=92) N (%) | Group B (N=151) N (%) | P value |
|---|---|---|---|
| Sex N (%) | 0.048 a | ||
| Female | 41 (44.6) | 47 (31.1) | |
| Male | 51 (55.4) | 104 (68.9) | |
| Age (mean ± SD) | 43.47 ± 12.37 | 45.45 ± 12.19 | 0.225 |
| ≥55 | 13 (14.3) | 43 (28.5) | 0.017 a |
| <55 | 78 (85.7) | 108 (71.5) | |
| Thyroid-related drugs | 0.714 | ||
| No | 91 (98.9) | 147 (97.4) | |
| Yes | 1 (1.1) | 4 (2.6) | |
| Hashimoto’s thyroiditis | 1 | ||
| Positive | 8 (8.7) | 12 (7.9) | |
| Negative | 84 (91.3) | 139 (92.1) | |
| Nodular goiter | 0.118 | ||
| Positive | 14 (15.2) | 12 (7.9) | |
| Negative | 78 (84.8) | 139 (92.1) | |
| Family history | 0.988 | ||
| Positive | 1 (1.1) | 3 (2.0) | |
| Negative | 91 (98.9) | 148 (98.0) | |
| Thyroid function b | |||
| TSH | 0.024 a | ||
| Positive | 33 (35.9) | 78 (51.7) | |
| Negative | 59 (64.1) | 73 (48.3) | |
| FT3 | 0.016 a | ||
| Positive | 28 (30.4) | 71 (47.0) | |
| Negative | 64 (69.6) | 80 (53.0) | |
| FT4 | 0.095 | ||
| Positive | 80 (87.0) | 142 (94.0) | |
| Negative | 12 (13.0) | 9 (6.0) | |
| T3 | 0.417 | ||
| Positive | 43 (46.7) | 80 (53.0) | |
| Negative | 49 (53.3) | 71 (47.0) | |
| T4 | 0.017 a | ||
| Positive | 82 (89.1) | 147 (97.4) | |
| Negative | 10 (10.9) | 4 (2.6) | |
| TgAb | 0.232 | ||
| Positive | 27 (29.3) | 57 (37.7) | |
| Negative | 65 (70.7) | 94 (62.3) | |
| TPOAb | 0.302 | ||
| Positive | 23 (25.0) | 63 (41.7) | |
| Negative | 69 (75.0) | 88 (58.3) | |
| Characteristics of US | |||
| Bilateral | 0.238 | ||
| No | 30 (32.6) | 62 (41.1) | |
| Yes | 62 (67.4) | 89 (58.9) | |
| Side N (%) | 0.317 | ||
| Right | 39 (42.4) | 79 (52.3) | |
| Left | 47 (51.1) | 63 (41.7) | |
| Isthmus | 6 (6.5) | 9 (6.0) | |
| Tumor Size N (%) | 0.074 | ||
| ≤10 mm | 54 (58.7) | 108 (72.0) | |
| >10 mm, ≤20 mm | 29 (31.5) | 35 (23.3) | |
| >20 mm | 9 (9.8) | 8 (4.7) | |
| Aspect Ratio N (%) | 0.331 | ||
| >1 | 68 (73.9) | 121 (80.1) | |
| <1 | 24 (26.1) | 30 (19.9)) | |
| Margin | 1 | ||
| Circumscribed | 14 (15.2) | 23 (15.2) | |
| Indistinct | 78 (84.8) | 128 (84.8) | |
| Microcalcification | 0.073 | ||
| Negative | 25 (27.2) | 59 (39.1) | |
| Positive | 67 (72.8) | 92 (60.9) | |
| Capsule Involvement | 0.186 | ||
| Negative | 73 (79.3) | 130 (86.1) | |
| Positive | 19 (20.7) | 21 (13.9) | |
| Internal Vascularity | 0.388 | ||
| Negative | 13 (14.1) | 29 (19.3) | |
| Positive | 79 (85.9) | 121 (80.7) | |
| TI-RADS | 0.042 a | ||
| 4A/4B | 18 (19.6) | 49 (32.5) | |
| 4C/5 | 74 (80.4) | 102 (67.5) | |
| Immunohistochemistry | |||
| MC | 0.451 | ||
| Negative | 6 (13.0) | 14 (20.3) | |
| Positive | 40 (87.0) | 55 (79.7) | |
| Gal3 | 0.393 | ||
| Negative | 8 (9.8) | 8 (5.7) | |
| Positive | 74 (90.2) | 132 (94.3) | |
| TTF1 | 0.061 | ||
| Negative | 17 (23.9) | 15 (12.4) | |
| Positive | 54 (76.1) | 106 (87.6) | |
| TPO | 0.245 | ||
| Negative | 75 (96.2) | 119 (90.8) | |
| Positive | 3 (3.8) | 12 (9.2) | |
| Ki67 ≥0.02, <0.02 | 0.101 | ||
| Negative | 24 (33.3) | 58 (46.4) | |
| Positive | 48 (66.7) | 67 (53.6) | |
| CKHi | 0.965 | ||
| Negative | 11 (19.6) | 15 (17.9) | |
| Positive | 45 (80.4) | 69 (82.1) | |
| Gene mutation | |||
| BRAF V600E | <0.001 a | ||
| Wild-type | 8 (8.7) | 85 (56.3) | |
| Mutant | 84 (91.3) | 66 (43.7) | |
| TERT C228T/250T | 0.663 | ||
| Wild-type | 90 (97.8) | 150 (99.3) | |
| Mutant | 2 (2.2) | 1 (0.7) | |
| KRAS G12C/G12V/Q61R | 1 | ||
| Wild-type | 91 (98.9) | 149 (99.3) | |
| Mutant | 1 (1.1) | 2 (0.7) | |
| HRAS Q61R | 1 | ||
| Wild-type | 92 (100) | 151 (100) | |
| Mutant | 0 | 0 | |
| NRAS Q61R | 1 | ||
| Wild-type | 92 (100%) | 151 (100%) | |
| Mutant | 0 | 0 | |
| CCDC6-RET | 1 | ||
| Wild-type | 92 (100%) | 151 (100%) | |
| Mutant | 0 | 0 | |
| PAX8-PPARG | 1 | ||
| Wild-type | 92 (100%) | 151 (100%) | |
| Mutant | 0 | 0 | |
| EVT6-NTRK3 | 1 | ||
| Wild-type | 92 (100%) | 151 (100%) | |
| Mutant | 0 | 0 | |
(a) Bold values indicate statistical significance (P<0.05). (b) The values of thyroid function were divided into positive and negative. Positive means outside the normal reference value range, and negative means within the normal reference value range.