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. 2023 Jan 25;13:1090592. doi: 10.3389/fonc.2023.1090592

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Copyright © 2023 Peiffer, Gambichler, Buus, Horny, Gravemeyer, Furtmann, Spassova, Kubat, Susok, Stranzenbach, Srinivas, Ødum and Becker

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The malignant T-cell clone and its subpopulations. (A) UMAP of all T cells (5,453) from the blood and skin biopsy color coded by TCR clonotype annotation. MalignantClone includes all cells with the TCR composed of TCRα: CAVTGARLMF; TCRβ: CSASTGGAYTEAFF. OtherClones includes all other TCRs. (B, C) UMAP of all T cells highlighted by sample origin (B) and cluster annotation (C). (D) CNV analysis using reactive T cells used as reference. Chromosomal gains are marked in red and chromosomal losses in blue. The x-axis shows the affected chromosomes. (E) Heat map of the top 10 differentially expressed genes of each annotated cluster. Two red rectangles are marking the malignant T cells with memory phenotype (upper) and cytotoxic phenotype (lower). (F) Volcano plot of the differentially expressed genes between the two major subpopulations of the malignant T-cell clone. (G) Feature plots highlighting the most discriminative genes from (E, F).