Table 1.
Definition of the four different mechanisms determining the overall level of ITN protection and the equations used for their estimation
| Direct net users |
Indirect (community effect) net users and non-users |
|
|---|---|---|
| Barrier | (a) Reduction in EIR due to reduced mosquito blood-feeding rate. | (b) Change in EIR for net users and non-users caused by lower human prevalence resulting from (a). Non-users may experience more bites from mosquitoes repelled away from net users |
| Calculated as | Calculated as | |
| Additional protection from insecticide | (c) Further reduction in EIR caused by insecticide killing and deterrence of blood-seeking mosquitoes | (d) Further reduction in EIR due to higher mosquito mortality, lower mosquito abundance and lower human prevalence resulting from (c) |
| Calculated as | Calculated as |
The four mechanisms (defined a–d) are described according to their impact on transmission. Direct benefits occur to those using ITNs, whereas indirect benefits act upon everyone in a community where ITNs are in use. The value of each are estimated from a transmission dynamics mathematical model, with the different scenarios (italic upper case letters) refer to model run with different assumptions presented in Fig. 2.