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. 2022 Feb 23;37(3):524–530. doi: 10.1038/s41433-022-01978-8

Table 2.

Associations (univariate analysis) between the reduction or increase of the ophthalmoscopical optic disc size in the Beijing eye Study 2001–2011.

Parameter Odds ratio 95% confidence interval p value Odds ratio 95% confidence interval p value
Reduction in optic disc size Increase in optic disc size
Axial length 1.19 0.95, 1.50 0.13 1.57 1.15, 2.14 0.004
Highly myopic group versus non-highly myopic group 5.74 2.36, 14.0 <0.001 6.73 2.21, 20.5 0.001
Increase in the stage of myopic maculopathy 0.58 0.21, 1.58 0.29 1.49 0.88, 2.52 0.14
Elongation of the disc-fovea distance 4.73 2.15, 10.4 <0.001 4.92 1.94, 12.5 0.001
Parapapillary gamma zone presence in the year 2001 5.32 2.09, 13.6 <0.001 25.3 3.35, 191.9 0.002
Parapapillary gamma zone presence in the year 2011 34.0 4.53, 254.8 <0.001 20.4 2.70, 154.7 0.003
Gamma zone enlargement in one direction without circular gamma zone enlargement 24.5 9.2, 65.3 <0.001 1.44 0.61, 3.43 0.40
Circular enlargement of gamma zone 3.4;95 0.96, 12.1 0.06 4.46 1.79, 11.1 0.001
Gamma zone enlargement, any 51.2 6.82, 384 <0.001 29.8 3.93, 226 <0.001
Presence of delta zone in the year 2001 0.88 0.35, 2.20 0.78 5.48 2.25, 13.3 <0.001
Presence of delta zone in the year 2011 1.02 0.44, 2.39 0.96 6.16 2.55, 14.9 <0.001
Parapapillary delta zone enlargement 0.95 0.40, 2.29 0.91 7.10 2.91, 17.3 <0.001
Retinal vessel trunk shift in optic disc 17.6 6.90, 44.9 <0.001 16.1 5.54, 46.5 <0.001
Straightening of temporal retinal vessels 3.78 1.76, 8.01 0.001 4.88 1.98, 12.0 0.001
Decrease in angle kappa 4.03 1.86, 8.74 <0.01 6.22 2.25, 16.4 <0.001
Presence of macular Bruch’s membrane defects in the year 2001 1.89 0.17, 21.4 0.61 2.94 0.26, 33.7 0.39
Presence of macular Bruch’s membrane defects in the year 2011 0.82 0.17, 3.97 0.80 5.68 1.59, 20.3 0.007
Enlargement of macular BM defects 1.01 1.004, 1.021 0.003 1.00 0.99, 1.01 0.94