Table 2.

Experimental data of palbociclib solubility in ScCO₂.

T (K)	P (MPa)	${\rho }_{{\mathrm{CO}}_2}$a (kg∙m−3)	y × 105 (mole fraction)	Std (y) × 105 (mole fraction)b	U($\overline{y}$) × 105 (mole fraction)c	Solubility (g∙L−1)
308	12.0	769	0.391	0.012	0.027	0.0305
	15.0	817	0.501	0.024	0.053	0.0415
	18.0	849	0.552	0.021	0.047	0.0475
	21.0	875	0.627	0.011	0.034	0.0557
	24.0	896	0.697	0.012	0.036	0.0635
	27.0	914	0.914	0.021	0.056	0.0849
318	12.0	661	0.221	0.010	0.022	0.148
	15.0	744	0.349	0.015	0.033	0.264
	18.0	791	0.419	0.012	0.030	0.337
	21.0	824	0.738	0.011	0.038	0.618
	24.0	851	0.860	0.013	0.043	0.743
	27.0	872	1.242	0.041	0.096	0.1101
328	12.0	509	0.110	0.004	0.009	0.0057
	15.0	656	0.210	0.004	0.012	0.0140
	18.0	725	0.281	0.013	0.030	0.0206
	21.0	769	0.840	0.019	0.053	0.0656
	24.0	802	0.972	0.021	0.059	0.0792
	27.0	829	1.468	0.032	0.091	0.1235
338	12.0	388	0.081	0.003	0.007	0.0031
	15.0	557	0.137	0.002	0.007	0.0078
	18.0	652	0.211	0.003	0.011	0.0139
	21.0	710	0.981	0.041	0.093	0.0708
	24.0	751	1.197	0.011	0.057	0.0914
	27.0	783	2.027	0.091	0.202	0.1613

*Standard uncertainty values (u) for temperature and pressure are u(T) = 0.1 K and u(P) = 0.1 MPa.

^aCO₂ density was obtained from national institute of science and technology (NIST) chemistry webbook (http://webbook.nist.gov/chemistry/).

^bExperimental standard deviation was obtained by $Std\left(y_i\right)=\sqrt{{\sum }_j(y_j-\overline{y})/n-1}$.

^cExpanded uncertainty was determined from $U(\overline{y})=k·u_{\mathrm{comb}}$ with the coverage factor k = 2 (the level of confidence of approximately 95%) and the relative combined standard uncertainty $u_{\mathit{comb}}/\overline{y}=\sqrt{\sum _i{\left(P_i·u_i\left(x_i\right)/x_i\right)}^2}$.