Table 2.
The comparison of toxicity effects after lead and cadmium exposure (Saline; Chitosan@DOTAGA) evidencing the interest of an oral administration of Chitosan@DOTAGA.
| Groups | Control | Saline | Chitosan@DOTAGA |
|---|---|---|---|
| Blood Lead (µg L−1) | 68.2 ± 4.83 | 127.77 ± 18.32c | 108.23 ± 18.13b |
| Blood Cadmium (µg L−1) | 4.37 ± 1.24 | 7.75 ± 1.96b | 16.67 ± 13.89b |
| ALP (U L−1) | 259 ± 83 | 345 ± 183 | 201 ± 35 |
| ALT (U L−1) | 79 ± 55 | 65 ± 6 | 139 ± 136 |
| AST (U L−1) | 200 ± 88 | 201 ± 47 | 225 ± 78 |
| RBC (1012 L−1) | 8.39 ± 0.34 | 8.41 ± 1.05 | 8.82 ± 0.68 |
| WBC (109 L−1) | 7.61 ± 1.98 | 4.42 ± 2.55a | 6.43 ± 2.32 |
| HGB (g L−1) | 120.29 ± 5.68 | 116.33 ± 9.61 | 123.50 ± 2.43 |
| HCT (%) | 35.53 ± 1.36 | 35.68 ± 3.14 | 36.32 ± 1.13 |
| PLT (109 L−1) | 1031.71 ± 274.34 | 846.67 ± 155.22 | 1254.83 ± 297 |
| MCV (fL) | 42.14 ± 2.19 | 42.67 ± 2.34 | 41.17 ± 2.48 |
| MCH (pg) | 14.34 ± 0.63 | 13.90 ± 0.82 | 14.10 ± 1.18 |
| MCHC (g L−1) | 336.50 ± 2.81 | 326.50 ± 2.59d | 339.93 ± 10.83 |
ALP Alkaline phosphatase, ALT Alanine aminotransferase, AST Aspartate aminotransferase, RBC Red blood cell count, WBC White blood cell count, HGB Hemoglobin concentration, HCT Hematocrit, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration.
All relations are compared to the control and are non-significant, except those defined: ap < 0.05, bp < 0.01, cp < 0.001, dp < 0.0001.