FIGURE 5.
In vitro release of Rhodamine B from the MNs into the agarose hydrogel that acted as a skin model. (A) Schematic for the vitro release design. (B) Left: Snapshot showing the depthwise color change in the cross section of the agarose hydrogel after Rhodamine B (10 mg/ml) release from the microneedles over time. Right: Line graph of RGB color change of scanned image, analyzed with Photoshop software. X-axis represents the grey level at the corresponding position, and Y-axis indicates the grey levels of each color channel (Red, Green, Blue). PN MNs: physically crosslinked network MNs. Points represent means ± SD. (n = 3).