Table 4.
Comparison of clinical features between anti-p200 pemphigoid with mucosal lesions and other AIBD subtypes.
| Item | Anti-p200 pemphigoid | Anti-LM332-type MMP (55) | Anti-BP180-type MMP (332) | EBA (105) | ||||
|---|---|---|---|---|---|---|---|---|
| With mucosal lesions (sole p200 Ag-M, 36) | With mucosal lesions (multiple Ags-M, 16) | With only skin lesions (sole p200 Ag-S, 82) | With only skin lesions (multiple Ags-S, 20) | |||||
| Mucosal lesions | Oral | 27 in 36 (75.0%) | 12 in 16 (75.0%) | / | / | 50 in 55 (90.9%) * | 284 in 332 (85.5%) | 66 in 105 (62.9%) |
| Ocular | 3 in 36 (8.3%) | 3 in 16 (18.8%) | / | / | 25 in 55 (45.5%) * | 97 in 332 (29.2%) * | 3 in 105 (2.9%) | |
| Genital | 8 in 36 (22.2%) | 6 in 16 (37.5%) | / | / | 6 in 55 (10.9%) | 32 in 332 (9.6%) * | 7 in 105 (6.7%) * | |
| Nasal | 1 in 36 (2.8%) | 4 in 16 (25.0%) * | / | / | 1 in 55 (1.8%) | 11 in 332 (3.3%) | 1 in 105 (1.0%) | |
| Esophageal | 0 | 1 in 16 (6.3%) | / | / | 3 in 55 (5.5%) | 14 in 332 (4.2%) | 1 in 105 (1.0%) | |
| Pharyngeal | 0 | 1 in 16 (6.3%) | / | / | 11 in 55 (20.0%) * | 42 in 332 (12.7%) * | Unknown | |
| Laryngeal | 0 | 0 | / | / | 10 in 55 (18.2%) * | 35 in 332 (10.5%) | Unknown | |
| Lesion on single mucosa | 29 in 36 (80.6%) | 9 in 16 (56.2%) | / | / | Unknown | 127 in 200 (63.5%) * | Unknown | |
| Lesion on multiple mucosa | 7 in 36 (19.4%) | 7 in 16 (43.8%) | / | / | Unknown | Unknown | Unknown | |
| Skin lesions | 35 in 36 (97.2%) | 16 in 16 (100.0%) | 82 in 82 (100.0%) | 20 in 20 (100.0%) | 37 in 55 (67.3%) * | 132 in 332 (39.8%) * | 69 in 105 (65.7%) * | |
| Psoriasis | 0 | 1 in 16 (6.3%) | 26 in 82 (31.7%) * | 6 in 20 (30.0%) * | Unknown | Unknown | Unknown | |
| Malignancy | 1 in 36 (2.8%) | 1 in 16 (6.3%) | 1 in 82 (1.2%) | 0 in 20 (0.0%) | 8 in 55 (14.5%) | 21 in 332 (6.3%) | 7 in 105 (6.7%) | |
LM332, laminin 332; MMP, mucous membrane pemphigoid; EBA, epidermolysis bullosa acquisita; Ag, antigen; all 52 cases of anti-p200 pemphigoid with mucosal lesions were classified into 2 subgroups,(i) those with only p200 as autoantigen (sole p200 Ag-M subgroup) and (ii) those with p200 plus other autoantigens (multiple Ags-M subgroup); all 102 cases of anti-p200 pemphigoid with only skin lesions were also classified into 2 subgroups, (i) those with only p200 as autoantigen (sole p200 Ag-S subgroup) and (ii) those with p200 plus other autoantigens (multiple Ags-S subgroup); “/”, not applicable; *, p < 0.05 when compared with sole p200 Ag-M subgroup.