TABLE 2.
GRADE evidence profile.
| Outcomes (Trials) |
Quality assessment | Group | Clinical efficacy and safety | Quality | ||||||
| Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias |
Experiment | Control | Relative ratio (95% CI) |
Absolute (95% CI) | ||
| ORR (20) | Serious1 | No | No | No | Strongly suspected2 | 801/858 (93.1%) |
667/855 (78.5%) |
3.98 (2.91 to 5.45) | 154 more per 1,000 (from 132 more to 171 more) | ● ⊕⊕ ◯◯ low |
| PSQI (20) | Serious2 | No | No | No | None | 858 | 855 | No | 1.55 (1.97 to 1.13) | ⊕⊕⊕◯ Moderate |
ORR, objective response rate; PSQI, Pittsburgh Sleep Quality Scale.
1The included studies have certain defects in randomization, allocation concealment and blinding.
2There is evidence of publication bias, Egger’s test, p < 0.05.