Table 1.
Cancers with alterations of KLFs*.
| Tumor type | Expression level | |
|---|---|---|
| Decreased expression | Increased expression | |
| Bladder cancer | KLF4 | KLF5, KLF16 |
| Breast cancer | KLF2, KLF4, KLF6, KLF8-11, KLF14, KLF15, KLF17 | KLF5, KLF16 |
| Cervical cancer | KLF4 (of middle and low differentiation), KLF14 | KLF1, KLF4 (of high differentiation) |
| Clear cell carcinoma | KLF6 | |
| Colorectal cancer | KLF2-6, KLF6-SV2, KLF8-10, KLF12-15, KLF17 | KLF1, KLF4 (in spheroid cells), KLF5, KLF7, KLF16 |
| Cutaneous squamous cell carcinoma | KLF4 | |
| Endometrial cancer | KLF9 | |
| Esophagus cancer | KLF4 | KLF5 |
| Gastric cancer | KLF4, KLF6, KLF17 | KLF1, KLF5, KLF8, KLF16 |
| Glioma | KLF6, KLF9 | |
| Head and neck cancer | KLF6 | KLF5 (in cell nuclei), KLF6(with higher risk of local recurrence) |
| Hemangioma | KLF7 (during progressive phase, and in infantile cancer cells) | |
| Hepatocellular carcinoma | KLF2, KLF4, KLF6, KLF17 (during progressive phase) | KLF4 (with sorafenib resistance), KLF5, KLF8 |
| Leukemia | KLF3, KLF5 | |
| Lung cancer | KLF4-6, KLF17 | KLF7, KLF16 |
| Lymphoma | KLF4 | |
| Melanoma | KLF10 | KLF5 |
| Myeloma | KLF9, KLF10 | |
| Oral squamous cell carcinoma | KLF6 | KLF16 |
| Osteosarcoma | KLF3, KLF5, KLF8 | |
| Ovarian cancer | KLF4 | KLF8 |
| Pancreatic cancer | KLF9, KLF10 (with higher risk of distant metastasis) | KLF5 |
| Prostate cancer | KLF3-13, KLF17 | KLF1, KLF15, KLF16 |
| Retinoblastoma | KLF2 | KLF16 |
| Thyroid cancer | KLF17 | KLF5 |
KLF, Krüppel-like factor. *A more detailed version of this table with references can be found in Supplementary File S1 .