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. 2022 Nov 21;115(2):222–223. doi: 10.1093/jnci/djac213

Table 1.

Randomized trials: recurrence risk among women with early-stage breast cancer by menopausal hormone therapya

Hormone therapy use
No hormone
Total Breast cancer recurrence Total Breast cancer recurrence
Marsden (Col 2005) (6) 51 2 49 1
HABITS (Holmberg 2008) (3) 221 39 221 17
Stockholm (Fahlen 2013) (4) 188 60 190 48
      Total 460 101 460 66
a

Pooling data across the 3 trials yields a relative risk of 1.53 (95% confidence interval = 1.15 to 2.03).