Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 31;115(2):181–189. doi: 10.1093/jnci/djac196

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 1. — Case-control analysis of rare LoF variants (minor allele frequency [MAF] ≤ 0.005) and MS variants (MAF ≤ 0.001) in known or strongly proposed breast cancer genes, including subcategories of estrogen receptor–positive (ER+), ER-negative (ER-), and triple-negative (TN) breast tumor where diagnosis was available. ER+ and ER- groups were mutually exclusive, and the ER- groups include the TN samples. Participants without sufficient pathological information were only included in the overall LoF group and excluded from the subcategory analysis. CHEK2, BARD1, and BRIP1 were screened in 6689 cases and 14 381 controls; RAD51C and RAD51D were screened in 5726 cases and 13 428 controls. The sample sizes of ER+, ER-, and TN were 2146, 1246, and 862, respectively. CI = confidence interval; LoF = loss of function; MS = missense; OR = odds ratio (3,4,11,12,18,19).