Table 1.
Baseline characteristics of cases and controlsa
| Characteristics | Cases | Controls |
|---|---|---|
| Total No. | 11 872 | 11 013 |
| Age, mean (SD), y | 60.5 (12.2) | 63.2 (10.9) |
| Sex, No. (%) | ||
| Men | 6209 (52.3) | 5617 (51) |
| Women | 5663 (47.7) | 5396 (49) |
| Study, No. (%) | ||
| CCFR | 5073 (42.7) | 2180 (19.8) |
| CPSII | 790 (6.7) | 929 (8.4) |
| DACHS | 1966 (16.6) | 2744 (24.9) |
| DALS | 1083 (9.1) | 1148 (10.4) |
| EDRN | 188 (1.6) | 329 (3) |
| EPIC_Sweden | 145 (1.2) | 381 (3.5) |
| HPFS | 585 (4.9) | 591 (5.4) |
| MCCS | 490 (4.1) | 670 (6.1) |
| NFCCR | 489 (4.1) | 461 (4.2) |
| NHS | 764 (6.4) | 1197 (10.9) |
| NSHDS | 299 (2.5) | 383 (3.5) |
| Body mass index, No. (%) | ||
| 18.5 to <25 kg/m2 | 4154 (35) | 4510 (41) |
| 25 to <30 kg/m2 | 4991 (42) | 4650 (42.2) |
| ≥30 kg/m2 | 2727 (23) | 1853 (16.8) |
| Tobacco smoking, No. (%) | ||
| Never | 4947 (41.7) | 5156 (46.8) |
| Past or current | 6386 (53.8) | 5524 (50.2) |
| Unknown | 539 (4.5) | 333 (3) |
| Dietary intake | ||
| Red meat, mean (SD), servings/d | 0.8 (0.6) | 0.7 (0.6) |
| Processed meat, mean (SD), servings/d | 0.5 (0.4) | 0.4 (0.4) |
| Fruits, mean (SD), servings/d | 1.7 (1.5) | 1.8 (1.6) |
| Vegetables, mean (SD), servings/d | 2.3 (1.9) | 2.4 (2.0) |
| Fiber, mean (SD), g/d | 23.3 (10.8) | 23.1 (10.3) |
| Total energy, mean (SD), kcal/d | 2133 (866) | 2015 (767) |
| Education level, No. (%) | ||
| Less than high school graduate | 2382 (20.1) | 1776 (16.1) |
| High school graduate | 2872 (24.2) | 2605 (23.7) |
| Vocational or technical school or some college/university | 2971 (25) | 2310 (21) |
| Undergraduate or graduate degree | 3394 (28.6) | 4063 (36.9) |
| Missing | 253 (2.1) | 259 (2.4) |
| First degree relative with colorectal cancer, No. (%) | ||
| No | 8777 (73.9) | 9323 (84.7) |
| Yes | 2712 (22.8) | 1134 (10.3) |
| Missing | 383 (3.2) | 556 (5) |
| Location of colorectal cancer, No. (%) | ||
| Proximal colon | 4510 (38) | — |
| Distal colon | 3525 (29.7) | — |
| Rectum (includes rectosigmoid junction) | 3331 (28.1) | — |
| Missing | 506 (4.3) | — |
| Colorectal cancer stage, No. (%) | ||
| Stage 1 or local | 2747 (23.1) | — |
| Stage 2/3 or regional | 6785 (57.2) | — |
| Stage 4 or distant | 1214 (10.2) | — |
| Missing | 1126 (9.5) | — |
| Microsatellite instability, No. (%) | ||
| MSI-H | 1809 (15.2) | — |
| MSS/MSI-L | 8967 (75.5) | — |
| Missing | 1096 (9.2) | — |
| CpG island methylator phenotype, No. (%) | ||
| High | 1386 (11.7) | — |
| Low/negative | 7160 (60.3) | — |
| Missing | 3326 (28.0) | — |
| BRAF, No. (%) | ||
| Mutated | 1297 (10.9) | — |
| Wild type | 9423 (79.4) | — |
| Missing | 1152 (9.7) | — |
| KRAS, No. (%) | ||
| Mutated | 2961 (24.9) | — |
| Wild type | 6011 (50.6) | — |
| Missing | 2900 (24.4) | — |
a
CCFR = Colon Cancer Family Registry; CPSII = Cancer Prevention Study II; DACHS = Darmkrebs: Chancen der Verhutung durch Screening Study; DALS = Diet Activity and Lifestyle Study; EDRN = Early Detection Research Network; EPIC = European Prospective Investigation into Cancer and Nutrition; HPFS = Health Professionals Follow-up Study; MCCS = Melbourne Collaborative Cohort Study; MSS = microsatellite stable; NFCCR = Newfoundland Familial Colorectal Cancer Study; NHS = Nurses’ Health Study; NSHDS = Northern Sweden Health and Disease Study.