Table 2.

Association between body mass index and molecular subtypes of colorectal cancer^a,b

		Microsatellite instability		CpG island methylator phenotype		BRAF		KRAS
	CRC	MSS/MSI-L	MSI-H	CIMP-low/negative	CIMP-high	BRAF-wild type	BRAF-mutated	KRAS-wild type	KRAS-mutated
Exposure	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
Both sexes
No. cases	11 872	8967	1809	7160	1386	9423	1297	6011	2961
18.5 to <25 kg/m2	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)
25 to <30 kg/m2	1.18 (1.11 to 1.25)	1.18 (1.11 to 1.26)	1.20 (1.06 to 1.35)	1.20 (1.11 to 1.29)	1.20 (1.05 to 1.37)	1.20 (1.12 to 1.28)	1.17 (1.02 to 1.34)	1.24 (1.15 to 1.34)	1.13 (1.03 to 1.24)
≥30 kg/m2	1.47 (1.36 to 1.59)	1.47 (1.35 to 1.59)	1.55 (1.34 to 1.78)	1.39 (1.27 to 1.52)	1.67 (1.43 to 1.96)	1.47 (1.36 to 1.60)	1.54 (1.31 to 1.81)	1.54 (1.40 to 1.69)	1.40 (1.25 to 1.57)
Ptrend	<.001	<.001	<.001	<.001	<.001	<.001	<.001	<.001	<.001
Per 5 kg/m2	1.18 (1.15 to 1.22)	1.19 (1.15 to 1.23)	1.18 (1.12 to 1.24)	1.17 (1.12 to 1.21)	1.23 (1.16 to 1.31)	1.18 (1.15 to 1.23)	1.20 (1.13 to 1.28)	1.20 (1.16 to 1.25)	1.17 (1.12 to 1.22)
Pdifferencec		.91		.04		.35		.22
Men
No. cases	6209	4923	764	3954	528	5118	474	3144	1563
18.5 to <25 kg/m2	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)
25 to <30 kg/m2	1.19 (1.09 to 1.31)	1.22 (1.11 to 1.34)	1.06 (0.88 to 1.28)	1.20 (1.09 to 1.33)	1.16 (0.93 to 1.43)	1.19 (1.09 to 1.31)	1.25 (1.00 to 1.57)	1.28 (1.15 to 1.42)	1.11 (0.97 to 1.27)
≥30 kg/m2	1.51 (1.35 to 1.70)	1.53 (1.35 to 1.72)	1.43 (1.14 to 1.79)	1.42 (1.25 to 1.62)	1.56 (1.19 to 2.04)	1.52 (1.35 to 1.72)	1.44 (1.08 to 1.91)	1.52 (1.33 to 1.74)	1.44 (1.22 to 1.71)
Ptrend	<.001	<.001	.004	<.001	.002	<.001	.01	<.001	<.001
Per 5 kg/m2	1.24 (1.18 to 1.30)	1.25 (1.18 to 1.31)	1.16 (1.05 to 1.28)	1.22 (1.15 to 1.29)	1.22 (1.09 to 1.38)	1.24 (1.17 to 1.31)	1.20 (1.06 to 1.35)	1.24 (1.16 to 1.31)	1.21 (1.13 to 1.31)
Pdifferencec		.19		.89		.6		.54
Women
No. cases	5663	4044	1045	3206	858	4305	823	2867	1398
18.5 to <25 kg/m2	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)	1 (referent)
25-<30 kg/m2	1.17 (1.07 to 1.28)	1.16 (1.05 to 1.28)	1.27 (1.08 to 1.49)	1.20 (1.08 to 1.33)	1.23 (1.03 to 1.46)	1.22 (1.11 to 1.35)	1.10 (0.93 to 1.32)	1.21 (1.09 to 1.35)	1.17 (1.02 to 1.34)
≥30 kg/m2	1.44 (1.29 to 1.60)	1.43 (1.27 to 1.60)	1.57 (1.31 to 1.89)	1.36 (1.20 to 1.55)	1.74 (1.43 to 2.11)	1.44 (1.28 to 1.62)	1.60 (1.32 to 1.95)	1.57 (1.39 to 1.78)	1.37 (1.17 to 1.61)
Ptrend	<.001	<.001	<.001	<.001	<.001	<.001	<.001	<.001	.001
Per 5 kg/m2	1.15 (1.11 to 1.20)	1.16 (1.11 to 1.21)	1.17 (1.10 to 1.25)	1.14 (1.08 to 1.19)	1.23 (1.15 to 1.33)	1.16 (1.11 to 1.21)	1.19 (1.11 to 1.28)	1.19 (1.13 to 1.24)	1.14 (1.08 to 1.21)
Pdifferencec		.41		.008		.14		.18

^aControls are used as reference for all odds ratios. CI = confidence interval; CIMP = CpG island methylator phenotype; CRC = colorectal cancer; MSI = microsatellite instability; MSS = microsatellite stable; OR = odds ratio.

^bOdds ratios are adjusted for study, age, sex, smoking status, education, and red meat intake.

^cCase-only analyses used to calculate P_difference.