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. 2023 Jan 25;26(2):106056. doi: 10.1016/j.isci.2023.106056

Figure 7.

Figure 7

Model for B9 interaction with P36 and P52 for sporozoite host cell invasion

B9 may localize in distinct (1) or same (2) micronemes as P36 and P52. Upon microneme exocytosis, the three proteins are released onto the sporozoite surface where B9 could associate with P36 and P52, either as a membrane-bound form (3) or as a processed form (4). The complex may participate in direct or indirect interactions with host cell receptors, including CD81 and SRB1, to trigger commitment to productive host cell invasion.