H&E staining of UM tumors and regulation of protein expression in UM xenograft tumors. UM xenografted tumors were injected with miR-NC or miR-181a-5p twice per week for 3 weeks. H&E staining is shown (A), and Ki67 (B), cleaved-caspase3 (C), GNAQ (D) and AKT3 (E) expression was detected. The quantified protein levels are presented as a percentage of CTL (F). *P < 0.05, **P < 0.01, ***P < 0.001 vs. miR-NC.