Table 1. Correlation analysis between SLC7A11 and markers of immune cells for KICH in TIMER.
| Description | Gene markers | SLC7A11 | ||||
|---|---|---|---|---|---|---|
| None | Purity | |||||
| r | P | r | P | |||
| B cell | CD27 | 0.237 | 5.52e-02 | 0.352 | 3.99e-03 | |
| CD19 | 0.179 | 1.5e-01 | 0.225 | 7.18e-02 | ||
| CD38 | 0.282 | 2.18e-02 | 0.392 | 1.25e-03 | ||
| CD8+ T cell | CD8A | 0.151 | 2.26e-01 | 0.291 | 1.86e-02 | |
| CD8B | 0.157 | 2.08e-01 | 0.268 | 3.06e-02 | ||
| T cell (general) | CD3D | 0.194 | 1.18e-01 | 0.313 | 1.12e-02 | |
| CD3E | 0.223 | 7.24e-02 | 0.340 | 5.56e-03 | ||
| CD2 | 0.245 | 4.78e-02 | 0.391 | 1.26e-03 | ||
| Monocyte | CD14 | 0.119 | 3.40e-01 | 0.225 | 7.13e-02 | |
| CD115 | 0.183 | 1.40e-01 | 0.338 | 5.91e-03 | ||
| Tfh | BCL6 | 0.295 | 1.64e-02 | 0.279 | 2.42e-02 | |
| ICOS | 0.282 | 2.18e-02 | 0.381 | 1.75e-03 | ||
| CXCR5 | 0.100 | 4.25e-01 | 0.185 | 1.40e-01 | ||
| Th1 | T-bet (TBX21) | 0.088 | 4.80e-01 | 0.170 | 1.77e-01 | |
| STAT1 | 0.323 | 8.38e-03 | 0.355 | 3.66e-03 | ||
| STAT4 | 0.142 | 2.55e-01 | 0.271 | 2.92e-02 | ||
| IL12RB2 | 0.095 | 4.49e-01 | 0.110 | 3.81e-01 | ||
| WSX1(IL27RA) | 0.057 | 6.47e-01 | 0.171 | 1.73e-01 | ||
| IFN-γ (IFNG) | 0.094 | 4.51e-01 | 0.183 | 1.44e-01 | ||
| TNF-α (TNF) | 0.186 | 1.35e-01 | 0.268 | 3.11e-02 | ||
| Th2 | STAT6 | 0.022 | 8.58e-01 | 0.012 | 9.22e-01 | |
| GATA3 | −0.069 | 5.83e-01 | −0.065 | 6.08e-01 | ||
| STAT5A | 0.149 | 2.33e-01 | 0.225 | 7.14e-02 | ||
| CCR3 | 0.350 | 3.92e-03 | 0.383 | 1.65e-03 | ||
| Th9 | TGFBR2 | −0.081 | 5.18e-01 | −0.057 | 6.53e-01 | |
| PU.1(SPI1) | 0.143 | 2.51e-01 | 0.246 | 4.78e-02 | ||
| IRF4 | 0.186 | 1.34e-01 | 0.297 | 1.65e-02 | ||
| Th17 | IL-17A(IL17A) | NA | NA | NA | NA | |
| IL-21R(IL21R) | 0.237 | 5.55e-02 | 0.365 | 2.75e-03 | ||
| IL-23R(IL23R) | 0.109 | 3.83e-01 | 0.134 | 2.87e-01 | ||
| STAT3 | 0.332 | 6.67e-03 | 0.390 | 1.32e-03 | ||
| Th22 | AHR | 0.313 | 1.09e-02 | 0.329 | 7.41e-03 | |
| CCR10 | −0.177 | 1.55e-01 | −0.163 | 1.94e-01 | ||
| Treg | CD25(IL2RA) | 0.267 | 2.99e-02 | 0.369 | 2.47e-03 | |
| FOXP3 | 0.185 | 1.36e-01 | 0.238 | 5.67e-02 | ||
| CCR8 | 0.390 | 1.19e-03 | 0.441 | 2.37e-04 | ||
| T cell exhaustion | CTLA4 | 0.307 | 1.23e-02 | 0.416 | 5.59e-04 | |
| PD-1 (PDCD1) | 0.187 | 1.32e-01 | 0.288 | 2.00e-02 | ||
| TIM-3 (HAVCR2) | 0.096 | 4.40e-01 | 0.177 | 1.57e-01 | ||
| LAG3 | 0.236 | 5.70e-02 | 0.299 | 1.57e-02 | ||
| TAM | CD80 | 0.242 | 5.01e-02 | 0.306 | 1.32e-02 | |
| CD86 | 0.242 | 5.08e-02 | 0.387 | 1.46e-03 | ||
| CCL2 | 0.004 | 9.77e-01 | 0.068 | 5.90e-01 | ||
| CCR5 | 0.287 | 1.96e-02 | 0.420 | 5.03e-04 | ||
| Macrophage | CD68 | 0.251 | 4.23e-02 | 0.403 | 8.67e-04 | |
| CD11b (ITGAM) | 0.166 | 1.83e-01 | 0.317 | 1.01e-02 | ||
| M1 | IRF5 | 0.252 | 4.11e-02 | 0.353 | 3.88e-03 | |
| COX2 (PTGS2) | 0.158 | 2.04e-01 | 0.154 | 2.20e-01 | ||
| INOS (NOS2) | −0.074 | 5.53e-01 | −0.026 | 8.36e-01 | ||
| M2 | ARG1 | −0.037 | 7.69e-01 | −0.016 | 9.01e-01 | |
| CD16 (FCGR3B) | 0.169 | 1.75e-01 | 0.255 | 4.08e-02 | ||
| MRC1 | 0.094 | 4.52e-01 | 0.165 | 1.90e-01 | ||
| MS4A4A | 0.215 | 8.33e-02 | 0.371 | 2.34e-03 | ||
| Neutrophil | CD11b (ITGAM) | 0.166 | 1.83e-01 | 0.317 | 1.01e-02 | |
| CD15 (FUT4) | 0.305 | 1.32e-02 | 0.340 | 5.61e-03 | ||
| CD66b (CEACAM8) | −0.023 | 8.55e-01 | −0.023 | 8.56e-01 | ||
| Natural killer cell | CD7 | 0.137 | 2.73e-01 | 0.199 | 1.12e-01 | |
| XCL1 | 0.139 | 2.67e-01 | 0.196 | 1.17e-01 | ||
| KIR3DL1 | 0.039 | 7.58e-01 | 0.062 | 6.22e-01 | ||
| Dendritic cell | CD141(THBD) | −0.020 | 8.72e-01 | 0.028 | 8.27e-01 | |
| CD11c (ITGAX) | 0.210 | 9.10e-02 | 0.320 | 9.25e-03 | ||
| CD1C | 0.071 | 5.71e-01 | 0.168 | 1.81e-01 | ||
| Monocyte | CD14 | 0.119 | 3.40e-01 | 0.225 | 7.13e-02 | |
| CD16 (FCGR3B) | 0.169 | 1.75e-01 | 0.255 | 4.08e-02 | ||
| CD115 | 0.183 | 1.40e-01 | 0.338 | 5.91e-03 | ||
KICH, kidney chromophobe cell carcinoma; TIMER, Tumor Immune Estimation Resource.