Table 2. Correlation analysis between SLC7A11 and markers of immune cells for KIRC in TIMER.
| Description | Gene markers | SLC7A11 | ||||
|---|---|---|---|---|---|---|
| None | Purity | |||||
| r | P | r | P | |||
| B cell | CD27 | −0.024 | 5.8e-01 | −0.080 | 8.65e-02 | |
| CD19 | 0.101 | 1.94e-02 | 0.076 | 1.01e-01 | ||
| CD38 | 0.213 | 6.74e-07 | 0.181 | 9.31e-05 | ||
| CD8+ T cell | CD8A | 0 | 9.96e-01 | −0.047 | 3.11e-01 | |
| CD8B | −0.047 | 2.84 e-01 | −0.099 | 3.32e-02 | ||
| T cell (general) | CD3D | 0.004 | 9.27e-01 | −0.053 | 2.52e-01 | |
| CD3E | 0.029 | 5.11e-01 | −0.025 | 5.85e-01 | ||
| CD2 | 0.054 | 2.16e-01 | −0.359 | 9.84e-01 | ||
| Monocyte | CD14 | 0.222 | 2.21e-07 | 0.184 | 7.34e-05 | |
| CD115 | 0.219 | 3.33e-07 | 0.177 | 1.34e-04 | ||
| Tfh | BCL6 | 0.176 | 4.23e-05 | 0.216 | 2.97e-06 | |
| ICOS | 0.135 | 1.73e-03 | 0.112 | 1.59e-02 | ||
| CXCR5 | 0.177 | 3.82e-05 | 0.154 | 9.31e-04 | ||
| Th1 | T-bet (TBX21) | 0.027 | 5.26e-01 | 0.011 | 8.18e-01 | |
| STAT1 | 0.227 | 1.22e-07 | 0.197 | 2.00e-05 | ||
| STAT4 | 0.194 | 6.25e-06 | 0.192 | 3.26e-05 | ||
| IL12RB2 | 0.118 | 6.43e-03 | 0.127 | 6.16e-03 | ||
| WSX1 (IL27RA) | 0.256 | 1.96e-09 | 0.262 | 1.07e-08 | ||
| IFN-γ (IFNG) | 0.024 | 5.79e-01 | −0.009 | 8.42e-01 | ||
| TNF-α (TNF) | 0.066 | 1.26e-01 | 0.047 | 3.10e-01 | ||
| Th2 | STAT6 | 0.047 | 2.75e-01 | 0.087 | 6.21e-02 | |
| GATA3 | 0.03 | 4.83e-01 | −0.006 | 8.92e-01 | ||
| STAT5A | 0.111 | 1.03e-02 | 0.071 | 1.27e-01 | ||
| CCR3 | 0.156 | 3.07e-04 | 0.129 | 5.43e-03 | ||
| Th9 | TGFBR2 | 0.21 | 1.02e-06 | 0.213 | 4.09e-06 | |
| PU.1 (SPI1) | 0.128 | 3.11e-03 | 0.075 | 1.09e-01 | ||
| IRF4 | 0.208 | 1.32e-06 | 0.192 | 3.34e-05 | ||
| Th17 | IL-17A (IL17A) | 0.083 | 5.42e-02 | 0.11 | 1.82e-02 | |
| IL-21R (IL21R) | 0.245 | 9.43e-09 | 0.186 | 5.71e-05 | ||
| IL-23R (IL23R) | 0.202 | 2.65e-06 | 0.202 | 1.27e-05 | ||
| STAT3 | 0.215 | 5.41e-07 | 0.197 | 2.09e-05 | ||
| Th22 | AHR | 0.242 | 1.49e-08 | 0.261 | 1.25e-08 | |
| CCR10 | −0.002 | 9.62e-01 | −0.031 | 5.11e-01 | ||
| Treg | CD25 (IL2RA) | 0.404 | 2.31e-22 | 0.383 | 1.37e-17 | |
| FOXP3 | 0.182 | 2.31e-05 | 0.164 | 4.18e-04 | ||
| CCR8 | 0.271 | 1.95e-10 | 0.271 | 3.45e-09 | ||
| T cell exhaustion | CTLA4 | 0.093 | 3.16e-02 | 0.074 | 1.12e-01 | |
| PD-1 (PDCD1) | −0.028 | 5.13e-01 | −0.063 | 1.76e-01 | ||
| TIM-3 (HAVCR2) | −0.023 | 5.96e-01 | −0.045 | 3.36e-01 | ||
| LAG3 | −0.007 | 8.75e-01 | −0.055 | 2.43e-01 | ||
| TAM | CD80 | 0.256 | 2.14e-09 | 0.238 | 2.21e-07 | |
| CD86 | 0.234 | 4.68e-08 | 0.202 | 1.27e-05 | ||
| CCL2 | 0.012 | 7.82e-01 | 0.029 | 5.35e-01 | ||
| CCR5 | 0.13 | 2.65e-03 | 0.089 | 5.71e-02 | ||
| Macrophage | CD68 | 0.216 | 4.62e-07 | 0.217 | 2.57e-06 | |
| CD11b (ITGAM) | 0.235 | 4.06e-08 | 0.209 | 5.76e-06 | ||
| M1 | IRF5 | −0.037 | 3.98e-01 | −0.028 | 5.44e-01 | |
| COX2(PTGS2) | 0.36 | 8.93e-18 | 0.353 | 5.39e-15 | ||
| INOS (NOS2) | −0.037 | 3.94e-01 | −0.063 | 1.79e-01 | ||
| M2 | ARG1 | 0.014 | 7.43e-01 | 0.021 | 6.51e-01 | |
| CD16 (FCGR3A) | 0.192 | 7.83e-06 | 0.156 | 7.78e-04 | ||
| MRC1 | 0.328 | 7.29e-15 | 0.322 | 1.46e-12 | ||
| MS4A4A | 0.315 | 1.01e-13 | 0.294 | 1.25e-10 | ||
| Neutrophil | CD11b (ITGAM) | 0.235 | 4.06e-08 | 0.209 | 5.76e-06 | |
| CD15 (FUT4) | 0.239 | 2.37e-08 | 0.231 | 5.17e-07 | ||
| CD66b (CEACAM8) | 0.036 | 4.1e-01 | 0.049 | 2.89e-01 | ||
| Natural killer cell | CD7 | −0.026 | 5.43e-01 | −0.086 | 6.37e-02 | |
| XCL1 | 0.014 | 7.5e-01 | −0.033 | 4.76e-01 | ||
| KIR3DL1 | −0.007 | 8.69e-01 | −0.008 | 8.62e-01 | ||
| Dendritic cell | CD141 (THBD) | 0.216 | 4.81e-07 | 0.226 | 9.48e-07 | |
| CD11c (ITGAX) | 0.168 | 1.01e-04 | 0.16 | 5.72e-04 | ||
| CD1C | 0.107 | 1.37e-02 | 0.069 | 1.39e-01 | ||
| Monocyte | CD14 | 0.222 | 2.21e-07 | 0.184 | 7.34e-05 | |
| CD16 (FCGR3B) | 0.178 | 3.62e-05 | 0.197 | 2.01e-05 | ||
| CD115 | 0.219 | 3.33e-07 | 0.177 | 1.34e-04 | ||
KIRC, kidney renal clear cell carcinoma; TIMER, Tumor Immune Estimation Resource.