Table 1. Identification of drug for cuproptosis-related DEGs in PD.

Gene	Drug	Sources	PMIDs	Query score	Interaction score
ATP7B	Platinum	NCI	15213293	0.61	1.77
ATP7B	Oxaliplatin	NCI	15213293	0.23	0.67
ATP7B	Carboplatin	NCI, PharmGKB	26194361, 15213293	0.22	0.63
ATP7B	Daunorubicin	PharmGKB	25119182	0.13	0.39
ATP7B	Cisplatin	NCI	12509969, 11605050, 15213293	0.24	0.34
NFE2L2	Chembl128729	DTC	23742639	8.61	0.15
NFE2L2	Andalusol	DTC	23046382	8.61	0.15
NFE2L2	Lagascatriol	DTC	23046382	8.61	0.15
NFE2L2	Suforaphane_isoselenocyanate	DTC	20304643	8.61	0.15
NFE2L2	Dimethyl fumarate	DTC	23647822	4.3	0.08
NFE2L2	Chembl398412	DTC	21956953	2.87	0.05
NFE2L2	Irofulven	NCI	9195958	2.87	0.05
NFE2L2	Pyrazole	NCI	16374848	2.15	0.04
NFE2L2	Fibroblast growth factor-1	NCI	15870071	2.15	0.04
NFE2L2	Dicumarol	DTC, NCI	12584558	1.84	0.03
NFE2L2	Sulforaphane	DTC	20304643	1.23	0.02
NFE2L2	Bardoxolone methyl	DTC	26278028	1.08	0.02
NFE2L2	Lycopene	NCI	18566994	1.08	0.02
NFE2L2	Ionomycin	NCI	15294043	0.96	0.02
NFE2L2	Capsaicin	DTC, NCI	17979524	0.86	0.02
NFE2L2	Flutamide	DTC, NCI	16055512	0.68	0.01
NFE2L2	Hypericin	NCI	17219054	0.66	0.01
NFE2L2	Deferoxamine	NCI	16950787	0.61	0.01
NFE2L2	Epoetin beta	NCI	16707229	0.61	0.01
NFE2L2	Bromocriptine	NCI	18455424	0.54	0.01
NFE2L2	Wortmannin	DTC, NCI	12391262	0.46	0.01
NFE2L2	Tretinoin	DTC, NCI	18048326	0.45	0.01
NFE2L2	Bleomycin	NCI	15208274	0.45	0.01
NFE2L2	Rosiglitazone	NCI	18302760	0.37	0.01
NFE2L2	Epigallocatechin gallate	NCI	16950787	0.33	0.01
NFE2L2	Staurosporine	NCI	11035812	0.32	0.01
NFE2L2	Indomethacin	NCI	11909699	0.25	0
NFE2L2	Lithium	NCI	18619545	0.19	0
NFE2L2	Simvastatin	NCI	17928392	0.16	0
NFE2L2	Dexamethasone	DTC, NCI	15870285	0.16	0
NFE2L2	Sirolimus	NCI	17652445	0.15	0
NFE2L2	Curcumin	DTC	23742639	0.12	0
NFE2L2	Alcohol	NCI	18759561	0.1	0
NFE2L2	Doxorubicin	NCI	18413364	0.09	0

DEGs, differentially expressed genes; PD, Parkinson’s disease.