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. 2022 Dec 21;15(2):e16796. doi: 10.15252/emmm.202216796

Figure 8. IL‐4 mediates eosinophil effects on the inflammatory structure.

Figure 8

  1. Composite MELC image showing the disappearance of the pro‐ (PI) and the anti‐inflammatory (AI) regions 24 h after zymosan injection. Shown are representative images of mice receiving anti‐Siglec F or IL‐4c. The red dotted lines depict the area where the transition between the neighboring regions occurs.
  2. Relative distance of various immune cell types based on the likelihood for a direct neighborhood of macrophage subtypes in regard to zymosan at the 24 h after zymosan injection. Data are shown as the mean ± SEM (n = 5 mice).
  3. Zymosan‐induced thermal hypersensitivity in control or eosinophil‐depleted mice with or without IL‐4c treatment 24 h prior zymosan injection. The right panel shows the comparison of paw withdrawal latencies between the 4 treatment groups at the indicated time points. Data are shown as the mean ± SEM (n = 6 mice). Two‐way ANOVA/Bonferroni, *P < 0.05, **P < 0.01; ns, not significant.

Source data are available online for this figure.