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. 2023 Feb 6;11(2):e005267. doi: 10.1136/jitc-2022-005267

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Peripheral TGF-β, CD73 TO, and sCD73 levels across all dalutrafusp alfa cohorts. (A) TGF-β1 in plasma on-treatment with dalutrafusp alfa. (B) CD73 TO on B cells in whole blood on-treatment with dalutrafusp alfa. (C) Free sCD73 in plasma on-treatment with dalutrafusp alfa. (D) sCD73 activity in plasma on-treatment with dalutrafusp alfa. CD, cluster of differentiation; s, soluble; TGF, tumor growth factor; TO, target occupancy.