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. 2023 Jan 11;15(2):e16581. doi: 10.15252/emmm.202216581

Figure EV2. Validation of proximal tubular‐specific deletion of Lonp1 (cKO), physiological indexes of aged cKO mice, and mitochondrial morphology in UUO model.

Figure EV2

  • A
    LONP1 immunofluorescence staining of primary renal tubular epithelial cells (PTECs) isolated from WT and cKO mice. Scale bar: 20 μm.
  • B
    Western blot analysis for the expression of LONP1 in medulla, glomerular and PTECs.
  • C–G
    Body weight (n = 8 or 10), blood pressure (BP, n = 5 or 6), serum creatinine (Scr, n = 8 or 10), blood urea nitrogen (BUN, n = 8 or 10) and Masson's trichrome staining in elderly WT and cKO mice (18 months). Scale bar: 50 μm.
  • H
    Transmission electron microscopy images of the mitochondria in tubular cells in WT and cKO mice after UUO model. Scale bar: 1 μm.

Data information: Data are presented as mean ± SEM. Student's t‐test.

Source data are available online for this figure.