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. Author manuscript; available in PMC: 2024 Jan 25.
Published in final edited form as: Nat Prod Rep. 2023 Jan 25;40(1):89–127. doi: 10.1039/d2np00050d

Figure 7.

Figure 7.

NRPS-PKS hybrid enzymes. (A) Proposed swainsonine biosynthetic pathway. SwmK catalyzes the formation of indolizidine core. (B) Proposed pyrophen and campyrone biosynthetic pathway. AnATPKS is involved in the formation of amino acid-containing 𝛼-pyrone natural products. (C) Proposed tenuazonic acid biosynthetic pathway. A KS domain is fused with NRPS to catalyze cyclization and product release.