Table 3.
Factors associated with COVID-19 infection among BMT survivors
| Risk factors |
Univariate analysis |
Multivariable analysis |
||||
|---|---|---|---|---|---|---|
| HR ratio | 95% CI | P value | aHR ratio | 95% CI | P value | |
| Age at study participation | ||||||
| <65 y | REF | |||||
| ≥65 y | 0.54 | 0.37-0.79 | .002 | |||
| Race/ethnicity | ||||||
| Non-Hispanic White | REF | .03c | REF | .08∗ | ||
| African American | 1.49 | 0.77-2.87 | .23 | 1.50 | 0.75-3.02 | .25 |
| Hispanic | 1.67 | 1.03-2.69 | .04 | 1.56 | 0.95-2.57 | .08 |
| Other | 0.43 | 0.16-1.18 | .10 | 0.47 | 0.17-1.29 | .14 |
| Sex | ||||||
| Female | REF | |||||
| Male | 0.87 | 0.60-1.24 | .43 | |||
| Primary cancer | ||||||
| Leukemia + lymphoma | REF | .44 | REF | .10 | ||
| PCD | 1.31 | 0.86-2.00 | .21 | 1.51 | 0.96-2.39 | .08 |
| Other | 0.96 | 0.46-1.98 | .90 | 0.66 | 0.30-1.45 | .30 |
| Contact with COVID–19 test positive individuals (family members/friends/at work) | ||||||
| No | REF | REF | ||||
| Yes | 5.00 | 3.17-7.87 | <.001 | 4.48 | 2.82-7.12 | <.0001 |
| Always wears mask | ||||||
| No | REF | REF | ||||
| Yes | 0.47 | 0.31-0.73 | .001 | 0.49 | 0.31-0.77 | .002 |
| Always stays 6 feet away | ||||||
| No | REF | |||||
| Yes | 0.63 | 0.44-0.91 | .01 | |||
| Always washes hand | ||||||
| No | REF | |||||
| Yes | 1.06 | 0.74-1.52 | .74 | |||
| Annual household income | ||||||
| ≥$75 000 | REF | |||||
| <$75 000 | 1.34 | 0.92-1.95 | .13 | |||
| Education | ||||||
| ≥College | REF | .42∗ | ||||
| <High school | 1.38 | 0.85-2.24 | .19 | |||
| High school/college | 1.10 | 0.73-1.64 | .65 | |||
| Have insurance | ||||||
| No | REF | |||||
| Yes | 0.91 | 0.29-2.86 | .87 | |||
| Chronic health conditions | ||||||
| Grade 0-2 | REF | |||||
| Grade 3-4 | 1.17 | 0.81-1.68 | .40 | |||
| Employment | ||||||
| Retired | REF | .01∗ | REF | .057∗ | ||
| Employed | 1.84 | 1.19-2.84 | .006 | 1.45 | 0.91-2.30 | .12 |
| Not employed | 2.14 | 1.28-3.59 | .004 | 1.90 | 1.12-3.23 | .02 |
| BMT type | ||||||
| Autologous | REF | .72∗ | ||||
| Allogeneic without chronic GvHD | 0.84 | 0.51-1.38 | .49 | |||
| Allogeneic with chronic GvHD | 0.87 | 0.56-1.35 | .54 | |||
| BMT survivorsfollow-upyears | ||||||
| ≥20 y | REF | .58∗ | ||||
| <10 y | 1.03 | 0.64-1.65 | .92 | |||
| 10-19 y | 0.83 | 0.55-1.27 | .40 | |||
| BMT survivors conditioning intensity | ||||||
| Nonmyeloablative/reduced intensity | REF | |||||
| Myeloablative conditioning | 0.98 | 0.67-1.44 | .91 | |||
| Disease status at BMT | ||||||
| Standard risk | REF | |||||
| High-risk | 1.31 | 0.92-1.88 | .13 | |||
∗
P value for whole group. Bold values indicate significant associations.