Fig. 5. The treatment of mice models. Evaluation of the treatment of mice models with primary and distant B16F10 mice melanoma tumors upon intratumor injection of Ir-pbt-Bpa (3 mg kg−1) into the primary tumor and exposure to two-photon irradiation (750 nm, 50 mW, 5 min). (a) Schematic timeline of the treatment. (b) Photographs of the collected tumors 12 days after the treatment. (c) Change in the tumor volume of the primary tumor upon treatment. (d) Change in the tumor volume of the secondary tumor upon treatment. (e) Change of the weight of the animal models. (f) Histological examination of the secondary tumor with a hematoxylin and eosin stain 12 days after the treatment. (1) Control; (2) light only; (3) Ir-pbt-Bpa only; (4) Ir-pbt-Bpa + light. ***P < 0.001, **P < 0.01 and *P < 0.05, in comparison to control.
