Fig. 3.

The role of AI662270 in promoting atherosclerosis progression was eliminated by macrophage clearance. A–C, E Representative images of aortic root cross sections stained with H&E (A) and analysis (C), and oil red O (B) and analysis (E) from ApoE^−/− mice intravenously injected with Lv-AI662270 and Lv-null or saline, with or without liposomal clondronate (LC), fed with HFD for 16 weeks (Scale bar = 400 μm). D, F Representative oil red O staining of aortas (D) and analysis (F) of ApoE^−/− mice injected with Lv-AI662270 and Lv-null or saline,with or without LC, fed with HFD for 16 weeks. n = 6 mice, each dot denotes an individual animal. **p < 0.01 vs. mice in Lv-null treated mice in HFD, “ns” means no significance. Data are expressed as mean ± SEM