Table 4.

AI662270 promotes cardiac function decline in ApoE^−/− mice with high fat diet (HFD)

	CD	HFD	Lv-null + HFD	Lv-AI662270 + HFD
EF (%)	69.62 ± 4.32	48.72 ± 7.08***	52.89 ± 6.57	34.97 ± 3.17##
FS (%)	38.14 ± 3.25	23.63 ± 5.08***	23.93 ± 3.66	16.58 ± 1.50#
LVPW, d (mm)	0.83 ± 0.29	0.93 ± 0.28	0.93 ± 0.28	0.66 ± 0.17
LVPW, s (mm)	1.18 ± 0.32	1.28 ± 0.46	1.30 ± 0.27	0.82 ± 0.22
LVID, d (mm)	3.17 ± 0.37	3.74 ± 0.73	3.73 ± 0.70	4.47 ± 0.75
LVID, s (mm)	1.97 ± 0.31	3.05 ± 0.52**	2.84 ± 0.56	3.90 ± 0.45#
HR, (bmp)	507.83 ± 8.43	564.17 ± 3.75**	573.5 ± 11.2	606.17 ± 6.04##

n = 6. **p < 0.01 or ***p < 0.001 vs. mice in chow diet (CD); #p < 0.05 or ##p < 0.01 vs. Lv-null treated mice in high fat diet (HFD). Data are expressed as mean ± SEM