Table 2.
Multivariable Cox proportional hazards models for each genomic prognostic signature adjusted for PREDICT in (a) ER-positive and (b) ER-negative patients
| Model | Hazard ratio (95% CI) | Log-likelihood | Model fit p value | c-index (95%CI) | c-index optimism |
|---|---|---|---|---|---|
| (a) | |||||
| PREDICT | 2.72† (NA) | − 2860.6 | – | 0.687 (0.661–0.713) | – |
| Oncotype DX | 1 (0.99–1) | − 2859.1 | 0.0835 | 0.693 (0.667–0.718) | − 4.17 × 10–4 |
| EndoPredict | 1.13 (1.02–1.24) | − 2858 | 0.024 | 0.692 (0.666–0.717) | 0.003 |
| MammaPrint | 0.52 (0.17– 0.87) | − 2853.9 | 2.32 × 10–4 | 0.699 (0.674–0.724) | 6.72 × 10–4 |
| Prosigna | 1.58 (1.11– 2.05) | − 2858.7 | 0.0546 | 0.694 (0.668–0.719) | − 8.68 × 10–4 |
| (b) | |||||
| PREDICT | 2.72† (NA) | − 1072 | – | 0.667 (0.630–0.704) | – |
| Oncotype DX | 0.998 (0.986– 1.01) | − 1072 | 0.77 | 0.667 (0.63–0.704) | 0.011 |
| EndoPredict | 0.884 (0.657– 1.11) | − 1071.4 | 0.287 | 0.667 (0.630–0.705) | 0.007 |
| MammaPrint | 0.854 (0.196– 1.51) | − 1071.9 | 0.638 | 0.669 (0.632–0.706) | 0.005 |
| Prosigna | 0.252 (− 0.875–1.38) | − 1069.3 | 0.0166 | 0.661 (0.622–0.699) | 7.84 × 10–4 |
95% CI, 95% confidence interval
†Hazard ratio has been constrained to this value