Table 3.

Calibration of original and modified PREDICT models in the METABRIC cohort for (a) ER-positive and (b) ER-negative patients

Model	10-Year survival %	Difference	Difference optimism
(a)
METABRIC cohort	74.0	Reference	Reference
PREDICT	61.1	− 13	–
PREDICT + Oncotype DX	61.3	− 12.8	− 0.694
PREDICT + EndoPredict	61.6	− 12.5	− 0.711
PREDICT + MammaPrint	61.9	− 12.2	− 0.640
PREDICT + Prosigna	61.2	− 12.8	− 0.706
(b)
METABRIC cohort	58.5	Reference	Reference
PREDICT	49.7	− 8.8	–
PREDICT + Oncotype DX	50.5	− 8	− 0.307
PREDICT + EndoPredict	52.9	− 5.6	− 0.403
PREDICT + MammaPrint	48.3	− 10.2	− 0.150
PREDICT + Prosigna	56.2	− 2.3	− 0.336

In bold, reference survival (METABRIC cohort)