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. 2023 Feb 8;13:25. doi: 10.1186/s13578-023-00977-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Amino Acid Metabolism in Cancer Cells and Its Crosstalk with Other Signal Pathways. Exogenous and endogenous amino acids are metabolized in CRC cells to fuel the unique biosynthetic and energetic requirements of the tumor, and metabolic enzymes involved in amino acid metabolism are regulated y different signals. Brown boxes indicate metabolic enzymes. Blue boxes represent factors that alter amino acid metabolism