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Aflibercept Release Characteristics from DDS.
| Formulation | Estimated Total Drug Load (ug) | Initial Burst (first 24 hours) (%) | E.E. of Particles into Hydrogel (%) | Release Rate after 7 days (ug/day) | Release time achieved (days) | Final Percent Released (%) |
|---|---|---|---|---|---|---|
| AFL-DDS | 277.9 ± 8.4 | 24.1 ± 4.3 | 74.9 ± 2.5 | 0.37 (R2 = 0.88) | 203 | 69.4 ± 6.8 |
| Combo-DDS | 267.4 ± 2.2 | 20.2 ± 2.7 | 75.6 ± 0.4 | 0.58 (R2 = 0.95) | 224 | 89.7 ± 5.1 |
Data represented by mean ± SEM (n=3).
