Fig. 8. Metal complexes for imaging bacterial infections.

A, Structures of imaging agents. B, The structure of [⁶⁸Ga]-PVD-PAO1 (Ba) and static PET–CT imaging of [⁶⁸Ga]-PVD-PAO1 (Bb and Bc) compared with [⁶⁸Ga]-citrate (Bd) and [¹⁸F]-FDG (Be) in a mouse muscle-infection model 45 min post-injection of Pseudomonas aeruginosa in one thigh and Escherichia coli or sterile inflammation in the other thigh. C, The structure of [⁶⁸Ga]-DFO-B (Ca) and static PET–CT imaging of [⁶⁸Ga]-DFO-B in a mouse thigh-infection model 45 min post-injection with P. aeruginosa (Cb) or Staphylococcus aureus (Cc) (yellow arrows indicate site of infection). PET, positron-emission tomography; CT, computed tomography; PAI, P. aeruginosa infection; ECI, E. coli infection; SI, sterile inflammation; TAFC, triacetylfusarinine; FOXE, ferrioxamine E; PVD, pyoverdine; FDG, fluorodeoxyglucose; DFO-B, desferrioxamine-B; ID g⁻¹, injected dose per gram of tissue; kBq ml⁻¹, kilobecquerel per millilitre. Part B reprinted from ref. ²⁶⁷, under a Creative Commons licence CC-BY 4.0. Part C reprinted from ref. ²⁶⁸, under a Creative Commons licence CC-BY 4.0.