Figure 6. Age-related changes in peripheral blood T cell populations, independent of BCG-vaccination, are observed in aged macaques in the memory compartment.
PBMCs from adult and aged vaccinated macaques from the time points indicated were stained for surface markers and analyzed by flow cytometry. (A) Percentage of naive CD8+ T cell and (B) CD8+ effector memory T cell populations throughout the study timeline. (C) Percentage of naive CD4+ T cell and (D) CD4+ effector memory T cell populations throughout the study timeline. Naïve T cells defined as CD95+CD28− and effector memory T cells defined as CD95−CD28+. Student t test Adult vs Old, *p<0.05, **p<0.01, ***p<0.001. Adult, white bars and open circles; old, grey bars and black circles.