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. Author manuscript; available in PMC: 2023 Feb 8.
Published in final edited form as: Structure. 2021 Mar 11;29(7):768–777.e2. doi: 10.1016/j.str.2021.02.005

Figure 2. Release of B-Raf autoinhibition in the presence of the 14-3-3 dimer.

Figure 2.

The (A) root-mean-square fluctuation (RMSF) values, (B) distances between pSer365 and the basic residues in 14-3-3 dimer, and (C) distances between pSer729 and the basic residues in 14-3-3 dimer indicate the conformational changes in B-Raf in complex with 14-3-3 dimer upon pSer365 release (denoted as B-RafΔpS) and RBD-CRD release (denoted as B-RafΔpS,RBD–CRD).