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. Author manuscript; available in PMC: 2023 Feb 8.
Published in final edited form as: Structure. 2021 Mar 11;29(7):768–777.e2. doi: 10.1016/j.str.2021.02.005

Figure 3. Structural insights into B-Raf activation upon the release of pSer365 motif and RBD-CRD.

Figure 3.

(A) In the fully autoinhibited B-Raf in complex with 14-3-3 dimer, KD and CRD interact with 14-3-3 dimer.

(B–D) The salt bridges of (B) D565KD-K21214-3-3, (C) K253CRD-D22314-3-3, and (D) R271CRD-D361pSer365 show the changes upon the release of pSer365 motif and RBD-CRD.