Table 3.

Mutations of RNA-binding proteins linked to ALS/FTD spectrum.

Genes	RNA-binding proteins	Mutations	References
TARDBP	Yes	Missense	(Benajiba et al., 2009; Borroni et al., 2009)
FUS	Yes	Missense	(Broustal et al., 2010; Van Langenhove et al., 2010)
HNRNPA1	Yes	Missense	(Kim et al., 2013)
HNRNPA2/B1	Yes	Missense	(Kim et al., 2013)
TIA1	Yes	Missense	(Mackenzie et al., 2017)
MATR3	Yes	Missense	(Johnson et al., 2014)
TAF15	Yes	Missense	(Ticozzi et al., 2011)
EWSR1	Yes	Missense	(Couthouis et al., 2012)
ANG	Yes	Missense	(van Es et al., 2009)
GLE1	Yes	Multiple	(Kaneb et al., 2015)
SETX	Yes	Missense	(Chen et al., 2004)
ARHGEF28	Yes	Frameshift	(Droppelmann et al., 2013b)
SOD1	Yes	Missense	(Katz et al., 2012)
ATXN2	Yes	PolyQ expansions	(Elden et al., 2010)
C9orf72	RNA toxicity	G4C2 repeat expansion	(DeJesus-Hernandez et al., 2011)