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. 2023 Feb 8;299(3):102990. doi: 10.1016/j.jbc.2023.102990

Figure 7.

Figure 7

Mproinhibits the IFN-I signaling at multiple steps. Schematic representation of how Mpro antagonizes ISG production. DCP1A, mRNA-decapping enzyme 1a; HDAC, histone deacetylase; IFN, interferon; ISG, interferon-stimulated gene; IRF9, interferon regulatory factor 9; Mpro, main protease; STAT, signal transducer and activator of transcription.