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. 2023 Jan 27;19(1):e1011101. doi: 10.1371/journal.ppat.1011101

Fig 8. Changes in RNA-Pol2-S5p levels upon ING3 knockout combined with AZD5582 treatment are nearly unique to the HIV-1 provirus.

Fig 8

(A) Volcano plot comparing RNA-Pol2-S5p peaks between the NTC KO + DMSO (negative control) and ING3 KO + AZD5582 conditions. Highlighted peaks over the HIV-1 LTR (yellow circle), the body of the provirus (green circle), and downstream region of HIV-1 provirus (blue circle) are the regions of the highest RNA-Pol2-S5p fold change and are highly significant. Other regions with an absolute log2 fold change greater than 1 and a -log10 adjusted p-value > 2 are highlighted in pink. (B) Scatter plot showing all of the RNA-Pol2-S5p peaks rank ordered by fold change. Peaks are colored as in (A). The top three regions are the HIV-1 LTR, body of the HIV-1 provirus, and downstream region of the HIV-1 provirus. The next two regions overlap HCG27 and the histone cluster 2 spanning HIST2H4A-HIST2H4B. The region with the greatest reduction in RNA-Pol2-S5p signal overlaps PCGF3.