Table 2.
Publications included in the final systematic literature search
| Citation | Publication type | Title | Plant derived substance and drug target |
|---|---|---|---|
| Alpizar et al. 2013 [99] | Original research | Bimodal effects of cinnamaldehyde and camphor on mouse TRPA1 | Camphor as a TRPA1 agonist and antagonist |
| Andrè et al. 2009 [100] | Original research | Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents | Camphor as a TRPA1 antagonist and antitussive |
| Behrendt et al. 2004 [78] | Original research | Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay | Menthol as a TRPM8 agonist |
| Ben-Arye et al. 2011 [15] | Randomised controlled trial | Treatment of Upper Respiratory Tract Infections in Primary Care: A Randomized Study Using Aromatic Herbs | Menthol, camphor and eucalyptus as an antitussive |
| Bödding et al. 2007 [81] | Original research | Characterisation of TRPM8 as a pharmacophore receptor | Menthol as a TRPM8 agonist |
| Buday et al. 2018 [121] | Randomised controlled trial | Modulation of cough response by sensory inputs from the nose—role of trigeminal TRPA1 versus TRPM8 channels | Menthol as an antitussive |
| Cohen et al. 2012 [126] | Randomised controlled trial | Effect of Honey on Nocturnal Cough and Sleep Quality: A Double-blind, Randomized, Placebo-Controlled Study | Eucalyptus honey as an antitussive |
| Ghosh et al. 2020 [109] | Original research | Essential Oils from Monarda fistulosa: Chemical Composition and Activation of Transient Receptor Potential A1 (TRPA1) Channels | Thymol as a TRPA1 agonist |
| Johnson et al. 2018 [122] | Observational study | Menthol Cough Drops: Cause for Concern? | Menthol as an antitussive |
| Karashima et al. 2007 [93] | Comparative study | Bimodal action of menthol on the transient receptor potential channel TRPA1 | Menthol as a TRPA1 agonist and antagonist |
| Kenia et al. 2008 [20] | Randomised controlled trial | Does inhaling menthol affect nasal patency or cough? | Menthol and eucalyptus oil as an antitussive |
| Kumar et al. 2012 [124] | Original research | Effect of nitrogen insertion on the antitussive properties of menthol and camphor | Menthol and camphor as an antitussive |
| Kurohane et al. 2013 [94] | Original research | Lack of transient receptor potential melastatin 8 activation by phthalate esters that enhance contact hypersensitivity in mice | Menthol as a TRPM8 agonist |
| Laude et al. 1994 [125] | Original research | The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs | Menthol, camphor and eucalyptus as an antitussive |
| Lee et al. 2008 [111] | Original research | Thymol and related alkyl phenols activate the hTRPA1 channel | Thymol as a TRPA1 agonist |
| Macpherson et al. 2006 [92] | Comparative study | More than cool: Promiscuous relationships of menthol and other sensory compounds | Menthol and camphor as TRP channel agonist and antagonist |
| Mahieu et al. 2007 [83] | Original research | TRPM8-independent menthol-induced Ca2 + release from endoplasmic reticulum and Golgi | Menthol as a TRPM8 agonist |
| Mälkiä et al. 2007 [161] | Original research | Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors | Menthol as a TRPM8 agonist |
| Marsakova et al. 2012 [101] | Comparative study | Pore Helix Domain Is Critical to Camphor Sensitivity of Transient Receptor Potential Vanilloid 1 Channel | Camphor as a TRPV1 agonist |
| McKemy et al. 2002 [84] | Original research | Identification of a cold receptor reveals a general role for TRP channels in thermosensation | Menthol as a TRP channel agonist |
| Mergler et al. 2013 [79] | Comparative study | Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells | Menthol and eucalyptus as an agonist for TRPM8 |
| Millqvist et al. 2013 [118] | Randomised controlled trial | Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough | Menthol as an antitussive |
| Morice et al. 1994 [120] | Clinical trial | Effect of inhaled menthol on citric acid induced cough in normal subjects | Menthol as an antitussive |
| Paschke et al. 2017 [87] | Original research | Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products | Menthol as a TRPM8 agonist |
| Paul et al. 2010 [18] | Randomised controlled trial | Vapor Rub, Petrolatum, and No Treatment for Children With Nocturnal Cough and Cold Symptoms | Menthol, camphor and eucalyptus as an antitussive |
| Peier et al. 2002 [75] | Original research | A TRP channel that senses cold stimuli and menthol | Menthol as a TRPM8 agonist |
| Pertusa et al. 2014 [76] | Original research | Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain | Menthol as a TRPM8 agonist |
| Pertusa et al. 2018 [77] | Comparative study | Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison | Menthol as a TRPM8 agonist |
| Plevkova et al. 2013 [80] | Original research | The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol | Menthol as a TRPM8 agonist and antitussive |
| Sabnis et al. 2008 [40] | Original research | Human lung epithelial cells express a functional cold-sensing TRPM8 variant | Menthol as a TRPM8 agonist |
| Selescu et al. 2013 [102] | Original research | Camphor Activates and Sensitizes Transient Receptor Potential Melastatin 8 (TRPM8) to Cooling and Icilin | Camphor as a TRPM8 agonist |
| Takaishi et al. 2012 [106] | Original research | 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1 | Eucalyptus as agonist and antagonist for TRPM8 and TRPA1 |
| Voets et al. 2004 [91] | Original research | The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels | Menthol as a TRPM8 agonist |
| Wang et al. 2020 [112] | Original research | Thymol activates TRPM8-mediated Ca2 + influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice | Thymol as a TRPM8 agonist |
| Weil et al. 2005 [82] | Comparative study | Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8 | Menthol as a TRPM8 agonist |
| Willis et al. 2011 [85] | Original research | Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants | Menthol and eucalyptus as an agonist for TRPM8 |
| Wise et al. 2012 [119] | Randomised controlled trial | Sweet taste and menthol increase cough reflex thresholds | Menthol as an antitussive |
| Xiao et al. 2008 [95] | Original research | Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels | Menthol as a TRPA1 agonist |
| Xing et al. 2006 [90] | Original research | Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons | Menthol as a TRPM8 agonist |
| Xu et al. 2005 [46] | Original research | Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism | Camphor as a TRPV1 agonist |
| Xu et al. 2015 [110] | Original research | Action of thymol on spontaneous excitatory transmission in adult rat spinal substantia gelatinosa neurons | Thymol as a TRPA1 agonist |
| Zhang et al. 2018 [117] | Original research | 1,8-cineole decreases neuropathic pain probably via a mechanism mediating P2X3 receptor in the dorsal root ganglion | Use of eucalyptus in targeting pain via P2X3 pathway |
| Zhou et al. 2011 [86] | Comparative study | Sensitivity of bronchopulmonary receptors to cold and heat mediated by transient receptor potential cation channel subtypes in an ex vivo rat lung preparation | Menthol as a TRPM8 agonist |