Table 1.
The general characteristics of the included literatures.
| The included literature (author, yr of publication, nation) | Study design | Sample size | Gender (Male) | Age (yr) | Follow-up time (mo) | Hepatocirrhosis | HCC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ETV | TDF | ETV | TDF | ETV | TDF | ETV | TDF | ETV | TDF | ETV | TDF | ||||
| Guzellbulut et al,[9] 2021, Turkey | Retrospective study | 248 | 359 | 178 | 219 | 45.54 ± 13.69 | 43.69 ± 13.22 | 58.58 ± 37.9 | 46.96 ± 29.37 | 89 | 76 | 12 | 7 | ||
| Yip et al,[4] 2019, Taiwan, China | Retrospective study | 28041 | 1309 | 18094 | 591 | 53.4 ± 13.0 | 43.2 ± 13.1 | 3.7 (1.7–5.0) | 2.8 (1.4–4.5) | 3822 | 38 | 1386 | 8 | ||
| Choi et al,[3] 2018, Korea | Retrospective study | 11464 | 12692 | unknown | unknown | 49.3 | 48.6 | unknown | unknown | 2991 | 3488 | 590 | 394 | ||
| Ha I et al,[10] 2020, Korea | Retrospective study | 921 | 419 | 558 | 266 | 48 | 45 | unknown | unknown | 259 | 39 | 82 | 24 | ||
| Hsu et al,[12] 2018, Taiwan, China | Prospective study | 224 | 21 | unknown | unknown | unknown | unknown | unknown | unknown | unknown | unknown | 20 | 0 | ||
| Hsu et al,[5] 2019, multiple centers | Prospective study | 4837 | 700 | 3382 | 465 | 50.81 ± 0, 17 | 45.74 ± 0.47 | unknown | unknown | unknown | unknown | 285 | 13 | ||
| Kim et al,[6] 2019, Korea | Retrospective study | 1484 | 1413 | unknown | unknown | 48.2 | 48.8 | unknown | unknown | 499 | 411 | 138 | 102 | ||
| Lee et al,[14] 2019, Korea | Retrospective study | 1583 | 1439 | 841 | 926 | 46.66 | 47.29 | 51.5 | 36.4 | 567 | 483 | 84 | 50 | ||
| Oh et al,[16] 2020, Korea | Retrospective study | 753 | 807 | 480 | 503 | 48.7 ± 11.4 | 46.3 ± 11.2 | 4.7 ± 1.0 | 4.5 ± 1.1 | 315 | 310 | 34 | 45 | ||
| Shin et al,[19] 2020, Korea | Retrospective study | 894 | 900 | 597 | 571 | 52 ± 11 | 51 ± 11 | 72 | 72 | 440 | 375 | 74 | 31 | ||
| Wu et al,[21] 2017, China | Retrospective study | 313 | 106 | 230 | 74 | 47 ± 12.3 | 47.1 ± 12.1 | 49.1 ± 19.1 | 37.9 ± 7.2 | 94 | 29 | 21 | 8 | ||
| Yu et al,[22] 2018, Korea | Retrospective study | 406 | 176 | 272 | 104 | 18–84 | 20–84 | 6–119.4 | 6.3–119.4 | 148 | 77 | 31 | 7 | ||
| Chang et al,[7] 2021, Taiwan, China | Retrospective study | 5348 | 1900 | 3544 | 1302 | 54 ± 11.9 | 51 ± 12.2 | 39.6 ± 24.6 | 40.1 ± 22.1 | 1590 | 590 | 375 | 100 | ||
| Chen et al,[8] 2020, Taiwan, China | Retrospective study | 993 | 567 | 721 | 428 | 55.4 ± 11.7 | 54.5 ± 12.9 | 65.8 | 47.7 | 993 | 567 | 196 | 48 | ||
| Ha et al,[10] 2020, Korea | Retrospective study | 180 | 224 | 106 | 120 | 45.4 ± 10.8 | 44.5 ± 11.4 | 64 | 49.1 | 67 | 78 | 18 | 6 | ||
| Kim et al,[13] 2018, Korea | Retrospective study | 721 | 604 | 471 | 363 | 52 ± 11 | 50 ± 11 | 33 | 66 | 346 | 267 | 40 | 14 | ||
| Papatheodoridis et al,[17]2020, multiple nations | Retrospective study | 772 | 1163 | 538 | 827 | 52 ± 14 | 53 ± 13 | 51.6–114.0 | 64.8–115.2 | 166 | 358 | 50 | 93 | ||
| Pol et al,[18] 2021, France | Prospective study | 814 | 986 | 597 | 666 | 39.7–58.9 | 35.0–56.5 | 37.1–60.7 | 37.1–60.7 | 69 | 90 | 9 | 12 | ||
| Su et al,[20] 2020, US | Retrospective study | 2193 | 1094 | 2116 | 1039 | 56.5 ± 12.2 | 55.4 ± 12.4 | 67.2 | 56.4 | 453 | 228 | 167 | 85 | ||
| Na et al,[15] 2021, Korea | Retrospective study | 671 | 665 | 392 | 384 | 44–57 | 42–56 | 62.4 | 45.6 | 377 | 302 | 57 | 42 | ||
ETV = entecavir, HCC = hepatocellular carcinoma, TDF = tenofovir.