Table 2.
ECMO run variables.
| ECMO run variables | All patients (n = 69) | Optimal PEEP group (n = 44) | Standard PEEP group (n = 25) | P value |
|---|---|---|---|---|
| Mean PEEP on ECMO day 2 (cm H20) | 15.3 | 17.9 | 10.8 | <0.0001 |
| Mean PEEP on ECMO day 7 (cm H20) | 13.4 | 14.1 | 11.5 | 0.079 |
| Mean driving pressure on ECMO day 2 (cm H20) | 9.37 | 9.53 | 10.2 | 0.665 |
| Mean driving pressure on ECMO day 7 (cm H20) | 10.5 | 10.6 | 10.1 | 0.370 |
| Sedative infusion at ECMO day 2, n (%) | 55 (79.7) | 37 (84.1) | 18 (72.0) | 0.350 |
| Mean RASS at ECMO day 2 | −2.16 | −2.27 | −1.96 | 0.219 |
| Sedative infusion at ECMO day 7, n (%) | 48 (69.6) | 36 (81.8) | 12 (48.0) | 0.006 |
| Mean RASS at ECMO day 7 | −1.66 | −1.76 | −1.48 | 0.365 |
| Mean ECMO RPM at 48 h | 3159 | 3131 | 3208 | 0.855 |
| Mean ECMO blood flow at 48 h (L/min) | 4.26 | 4.32 | 4.15 | 0.558 |
| Mean ECMO sweep gas flow at 48 h (L/min) | 6.62 | 6.70 | 6.48 | 0.923 |
| Mean ECMO FSO2 at 48 h | 89.9 | 85.3 | 98.0 | 0.001 |
| Extubated on ECMO, n (%) | 21 (30.4) | 3 (6.82) | 18 (72.0) | <0.0001 |
| Reintubated, n (%) | 12 (17.4) | 2 (4.55) | 10 (40.0) | 0.0004 |
| Tracheostomy, n (%) | 35 (50.1) | 24 (54.5) | 11 (44.0) | 0.458 |
| VTE, n (%) | 37 (53.6) | 25 (56.8) | 12 (48.0) | 0.616 |
| Vasopressors, n (%) | 59 (85.5) | 40 (90.9) | 19 (76.0) | 0.152 |
| CRRT, n (%) | 37 (53.6) | 25 (56.8) | 12 (48.0) | 0.616 |
| Proning on ECMO, n (%) | 10 (14.5) | 10 (22.7) | 0 (0) | 0.011 |
| Post-cannulation culture data positivity | ||||
| Blood, n (%) | 29 (42.0) | 20 (45.5) | 9 (36.0) | 0.612 |
| Urine, n (%) | 13 (18.8) | 8 (18.2) | 5 (11.36) | >0.999 |
| Sputum, n (%) | 54 (78.3) | 35 (79.5) | 19 (76.0) | 0.767 |
PEEP = positive end-expiratory pressure, ECMO = extracorporeal membrane oxygenation, RASS = Richmond Agitation Sedation Scale, RPM = rotations per minute, FSO2 = oxygen fraction of the sweep gas, VTE = venous thromboembolism, CRRT = continuous renal replacement therapy. Bold values are those with a significant p value.