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. 2023 Feb 8;9(6):eadf4144. doi: 10.1126/sciadv.adf4144

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Fig. 5. — Mice were 2 months old. (A and B) Spectra of acoustic emission recorded from WT, Foxg1-Cx26^+/−, and Foxg1-Cx26^−/− mice. DPOAEs were evoked by two-tone stimulation. f₀ = 16 kHz, I₁/I₂ = 60/55 dB SPL. Insets: Large-scale plots of 2f₁-f₂ and f₁ peaks. The peak of 2f₁-f₂ in Foxg1-Cx26^+/− mice was increased, while f₁ and f₂ peaks remained the same as those in WT mice. A pink trace in (B) represents no DPOAE peak visible in Foxg1-Cx26^−/− mice. (C) DPOAE in Foxg1-Cx26^+/− mice is increased in comparison with WT mice. I/O function of DPOAE in Foxg1-Cx26^+/− was shifted up to ~10 dB SPL. No DPOAE is visible in Foxg1-Cx26^−/− mice. (D) DP gain (2f₁-f₂ re: f₁) in Foxg1-Cx26^+/− mice. In comparison with WT mice, DP gain in Foxg1-Cx26^+/− mice was significantly increased by 5 to 10 dB. *P < 0.05 and **P < 0.01, two-tailed t test.