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. 2023 Feb 8;9(6):eadf4144. doi: 10.1126/sciadv.adf4144

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Fig. 8. — Both Pax2-Cx26^+/− and WT mice were exposed to 96 dB SPL of white noise for 2 hours, one time. The noise-exposed day is defined as day 0. ABR thresholds were normalized to the pre-noise exposure levels. (A and B) Changes of ABR thresholds in Cx26^+/− and WT mice after noise exposure. Vertical arrows indicate the noise exposure day. ABRs in (A) and (B) were evoked by 16 and 40 kHz of tone bursts, respectively. In comparison with WT mice, ABR thresholds in Cx26^+/− mice were not completely recovered after noise exposure; the ABR thresholds in Cx26^+/− mice have ~10 dB SPL of permanent threshold shift. (C) Changes of ABR thresholds in frequency range in Cx26^+/− and WT at P1. In comparison with WT mice, Cx26^+/− mice have a large ABR threshold increase in a high-frequency range. (D) ABR threshold shift in Cx26^+/− mice at P90. In comparison with control Cx26^+/− mice without noise exposure; noise-exposed Cx26^+/− mice at 3 months after noise exposure have ~10 dB SPL of increase in ABR thresholds in all tested frequency ranges. *P < 0.05 and **P < 0.01, two-tailed t test.