Espin‐Basany 2005.

Study characteristics
Methods	Study design: Parallel‐group randomised trials Duration of trial: ‐ Duration of follow‐up: 30 days Country of origin: Spain
Participants	Baseline characteristics Number randomised: 306 participants Number analysed: 300 participants Intervention 1: MBP+oAB Number of participants [n]: 100 Age [years; mean]: 66.6 Gender [male/female; n]: 63/37   Intervention 2: MBP+oAB Number of participants [n]: 100 Age [years; mean]: 67 Gender [male/female; n]: 67/33   Control: nBP Number of participants [n]: 100 Age [years, mean]: 69 Gender [male/female; n]: 62/38   Inclusion criteria  Quote: "Patients with elective colorectal resections" Exclusion criteria Quote: Pregnancy, penicillin allergy (cross reactions with cephalosporins) and contra‐in dications for a sodium phosphate (NaP) preparation (renal impairment with serum creatinine over 200 μg/l, massive ascites or severe heart failure)" Baseline imbalances "Treatment groups were similar, regarding age, sex, medical history of diabetes mellitus, hypertension or chronic obstructive pulmonary disease (COPD), preoperative serum albumin level and haematocrit, preoperative final diagnosis and operations performed"
Interventions	Comparison Intervention 1: MBP+oAB (3x) Intervention 2: MBP+oAB (1x) Control: MBP   MBP Agent(s): NaP oral solution (fosfosoda) Dose per administration: 45 mL in 90 mL water Time(s) of intake: before 11:00 AM and 5:00 PM on the day before surgery Route:oral Concomitant medications: ‐   oAB (3x) Agent(s): neomycin and metronidazole Dose per administration: 1 g each Time(s) of intake: at 3:00 PM, 7:00 PM and 11:00 PM Route: oral Concomitant medications: ‐   oAB (1x) Agent(s): neomycin and metronidazole Dose per administration: 1 g each Time(s) of intake: at 3:00 PM Route: oral Concomitant medications: ‐   Perioperative intravenous antibiotic prophylaxis Agent(s): cefoxitin Dose per administration: 1 g Time(s) of intake: before skin incision and two postoperative doses at 8 and 16 h postoperatively   Adherence to regimen: ‐
Outcomes	Outcomes sought in review and reported in trial SSI Incidence of postoperative ileus Side effects of Intervention(s) Outcomes sought but not reported in trial Anastomotic leakage Mortality Postoperative complications (mild D/C I + II or severe D/C III+IV) Length of hospital stay Outcomes reported in trial but not used in review ‐
Notes	Source of funding: ‐ Conflicts of interest: ‐ Ethics approval: ‐ Informed consent: Quote: "Threehundred consecutive patients with elective colorectal resections who consented to participate in the study were included." Clinical trials registration: ‐ Sample size calculation: ‐