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. 2023 Feb 7;2023(2):CD014909. doi: 10.1002/14651858.CD014909.pub2

Ishida 2001.

Study characteristics
Methods Study design:  Parallel‐group randomised trials
Duration of trial: April 1998 to August 2000
Duration of follow‐up: Quote: ""The wounds were inspected daily until the patients were discharged from the hospital."
Country of origin: Japan
Participants Baseline characteristics
Number randomised: 146 participants
Number analysed: 143 participants
Intervention: MBP+oAB
  • Number of participants [n]: 72

  • Age [years; mean (range)]: 62 (37‐87)

  • Gender [male/female; n]: 47/25


Control: MBP
  • Number of participants [n]: 71

  • Age [years, mean (range)]: 65 (21‐89)

  • Gender [male/female; n]: 42/29


Inclusion criteria 
Quote: ""Patients with colorectal diseases, surgically treated"
Exclusion criteria
Quote: ""The patients in both groups were excluded if a full mechanical bowel preparation was not feasible or if they had taken any antibiotics within 14 days before surgery"
Baseline imbalances
none
Interventions Comparison
  • Intervention: MBP+oAB

  • Control: MBP


MBP
  • Agent(s): polyethylene glycol lavage

  • Dose per administration: 2000 mL

  • Time(s) of intake: on the day prior to surgery (15:00–19:00 h)

  • Route: oral

  • Concomitant medications: ‐


oAB
  • Agent(s): kanamycin and erythromycin

  • Dose per administration: 500 mg and 400 mg

  • Time(s) of intake: four doses per day for 2 days before surgery

  • Route:oral

  • Concomitant medications: ‐


Perioperative intravenous antibiotic prophylaxis
  • Agent(s): cefotiam

  • Dose per administration: 1 g

  • Time(s) of intake: Quote: ""after the induction of anesthesia, and then again within 1 h after completing surgery. An additional four doses were given twice a day for 2 consecutive days. Patients with renal dysfunction were not given additional doses of cefotiam when appropriate."


Adherence to regimen: ‐
Outcomes Outcomes sought in review and reported in trial
  • SSI

  • Anastomotic leakage


Outcomes sought but not reported in trial
  • Mortality

  • Postoperative complications (mild D/C I + II or severe D/C III+IV)

  • Incidence of postoperative ileus

  • Length of hospital stay

  • Side effects of Intervention(s)


Outcomes reported in trial but not used in review
  • MRSA infection

Notes Source of funding:
Conflicts of interest:
Ethics approval:
Informed consent:
Clinical trials registration:
Sample size calculation: